4810-42-8

Basic information

• Product Name: N,N-diethylpyridine-3-sulfonamide
• CAS NO: 4810-42-8
• Molecular Formula: C₉H₁₄N₂O₂S
• Molecular Weight: 214.2847
• Mol File: 4810-42-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 336.8°C at 760 mmHg
• Flash Point: 157.5°C
• Density: 1.182g/cm³
• Vapor Pressure: 0.00011mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: N,N-diethylpyridine-3-sulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-diethylpyridine-3-sulfonamide(4810-42-8)
• EPA Substance Registry System: N,N-diethylpyridine-3-sulfonamide(4810-42-8)

Safety Data

• Hazardous Substances Data: 4810-42-8(Hazardous Substances Data)

Usage

General Description

N,N-diethylpyridine-3-sulfonamide, also known as DEET, is a widely used insect repellent that effectively protects against mosquito and tick bites. It works by blocking the insects’ olfactory receptors, making it difficult for them to locate and feed on the skin. DEET is available in various forms, such as lotions, sprays, and wipes, and is considered safe when used according to label instructions. While there have been some concerns about its potential health and environmental effects, studies have shown that DEET is generally safe for human use and does not pose significant risks when used in recommended doses. Overall, DEET is a valuable tool for preventing insect-borne diseases and providing protection in outdoor settings.

Upstream product

• 16133-25-8 Pyridine-3-sulfonyl chloride 
• 121-44-8 triethylamine 
• 636-73-7 3-pyridinesulfonic acid 
• 110-86-1 pyridine 
• 626-55-1 3-Bromopyridine 
• 109-89-7 diethylamine 

Relevant articles and documents

Nucleophilic C-H Etherification of Heteroarenes Enabled by Base-Catalyzed Halogen Transfer

We report a general protocol for the direct C-H etherification of N-heteroarenes. Potassium tert-butoxide catalyzes halogen transfer from 2-halothiophenes to N-heteroarenes to form N-heteroaryl halide intermediates that undergo tandem base-promoted alcohol substitution. Thus, the simple inclusion of inexpensive 2-halothiophenes enables regioselective oxidative coupling of alcohols with 1,3-azoles, pyridines, diazines, and polyazines under basic reaction conditions.

Efficient and scalable synthesis of pyridine sulfonamides

Short-step and scalable transformations from 2,6-dibromopyridine to 6-bromopyridine-2-sulfonamide by means of halogen-metal exchange and subsequent reaction with sulfuryl chloride followed by amidation are established. Application of the method for the synthesis of various pyridine sulfonamides is also described. Georg Thieme Verlag Stuttgart - New York.

Facile one-pot synthesis of aromatic and heteroaromatic sulfonamides

A series of arene and heteroarene sulfonamides were prepared in one vessel from aryl and heteroaryl bromides via conversion into the corresponding Grignard reagents using either magnesium or isopropylmagnesium chloride and subsequent reaction with sulfur dioxide, sulfuryl chloride, and an amine.