568591-14-0

Basic information

• Product Name: Carbamic acid, [(5S)-6-(benzoyloxy)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-[[( 1R)-1-phenylethyl]amino]heptyl]-, phenylmethyl ester
• CAS NO: 568591-14-0
• Molecular Formula: C35H43N3O7
• Molecular Weight: 617.742
• Mol File: 568591-14-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Carbamic acid, [(5S)-6-(benzoyloxy)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-[[( 1R)-1-phenylethyl]amino]heptyl]-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(5S)-6-(benzoyloxy)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-[[( 1R)-1-phenylethyl]amino]heptyl]-, phenylmethyl ester(568591-14-0)
• EPA Substance Registry System: Carbamic acid, [(5S)-6-(benzoyloxy)-5-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-[[( 1R)-1-phenylethyl]amino]heptyl]-, phenylmethyl ester(568591-14-0)

Safety Data

• Hazardous Substances Data: 568591-14-0(Hazardous Substances Data)

Upstream product

• 82689-16-5 benzyl {(5S)-5-[(tert-butoxycarbonyl)amino]-6-oxohexyl}carbamate 
• 17329-20-3 (R)-(+)-α-methylbenzylisocyanide 
• 65-85-0 benzoic acid 

Downstream Products

• 716329-38-3 [(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-(3-methyl-ureido)-pentyl]-carbamic acid 1-isopropyl-2-methyl-propyl ester 
• 568591-22-0 {(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-(4-fluoro-benzyl)-cyclobutylmethyl ester 
• 568591-24-2 {(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid 1-pyridin-4-ylmethyl-cyclobutylmethyl ester 
• 568591-30-0 [(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-(3-methyl-ureido)-pentyl]-carbamic acid 1-(2,6-difluoro-benzyl)-cyclobutylmethyl ester 
• 568591-17-3 {(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-[(morpholine-4-carbonyl)-amino]-pentyl}-carbamic acid tert-butyl ester 
• 568591-19-5 Morpholine-4-carboxylic acid [(S)-5-amino-6-hydroxy-6-((R)-1-phenyl-ethylcarbamoyl)-hexyl]-amide 
• 568591-27-5 [(S)-1-[Hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-5-(3-methyl-ureido)-pentyl]-carbamic acid tert-butyl ester 
• 568591-16-2 {(S)-5-Amino-1-[hydroxy-((R)-1-phenyl-ethylcarbamoyl)-methyl]-pentyl}-carbamic acid tert-butyl ester 
• 716329-37-2 (S)-3-Amino-2-hydroxy-7-(3-methyl-ureido)-heptanoic acid ((R)-1-phenyl-ethyl)-amide 
• 568591-15-1 [(S)-5-tert-Butoxycarbonylamino-6-hydroxy-6-((R)-1-phenyl-ethylcarbamoyl)-hexyl]-carbamic acid benzyl ester 

Relevant articles and documents

Orally bioavailable small molecule ketoamide-based inhibitors of cathepsin K

An orally available series of ketoamide-based inhibitors of cathepsin K has been identified. Starting from a potent inhibitor with poor oral bioavailability, modifications to P1 and P 1′ elements led to enhancements in solubility and permeability. These improvements resulted in orally available cathepsin K inhibitors.