58-56-0 Usage
Description
Pyridoxine hydrochloride, also known as vitamin B6 hydrochloride, is a water-soluble vitamin and a pyrimidine derivative of vitamin B6. It is a white or almost white, crystalline powder that is soluble in water and slightly soluble in alcohol. Pyridoxine hydrochloride is considered heat and acid stable, with a pH of 2.3-3.5. It plays a crucial role in various biological processes, including the transportation of protein Bsu1 and contributing to thiamine uptake.
Uses
Used in Pharmaceutical Industry:
Pyridoxine hydrochloride is used as a supplement for the prevention and treatment of vitamin B6 deficiency. It is essential for the proper functioning of the nervous system, the synthesis of neurotransmitters, and the metabolism of amino acids.
Used in Food Industry:
Pyridoxine hydrochloride is used as a nutrient additive in the food industry to fortify various food products, ensuring an adequate intake of vitamin B6 for consumers.
Used in Cosmetic Industry:
Pyridoxine hydrochloride is used in the cosmetic industry as an ingredient in skincare products, where it helps promote skin health and maintain a youthful appearance.
Used in Research:
Pyridoxine hydrochloride is used in scientific research as a component of the B6 complex, which is involved in various cellular processes and can be studied for its effects on different biological systems.
Brand Name:
Hexa-Betalin (Lilly) is a brand name for pyridoxine hydrochloride, which is used as a supplement to treat vitamin B6 deficiency and related conditions.
Nutrition supplements
Pyridoxine hydrochloride is the hydrochloride salt of Vitamin B6. Vitamin B6 (B6) is a water-soluble vitamin, which can be found in various foods such as fish, poultry, whole grains, legumes, banana, nuts, and sesame.Vitamin B6 has an important role in the metabolism of amino acids as a coenzyme, pyridoxal 5'-phosphate.?
B6 may exert an anticolon tumor effect by the protection of the colon epithelium from damage in rats treated with 1,2-dimethylhidrazine (DMH) and to decreased lithocholic acid, a colon carcinogen. Vitamin B6 may prevent such diseases by lowering inflammation.
Biochem/physiol Actions
Vitamin B6 is an essential coenzyme for amino acid, carbohydrate and lipid metabolism. Pyridoxine serves as a primary source in multivitamins. Pyridoxine deficiency is associated with peripheral neuropathy.
Clinical Use
Vitamin B6
Safety Profile
Poison by intravenous route. Moderately toxic by ingestion, intramuscular, and subcutaneous routes. Human reproductive effects by ingestion and intramuscular routes: postpartum changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl.
Drug interactions
Potentially hazardous interactions with other drugs
None known
Metabolism
Pyridoxine is metabolised to its active form pyridoxamine
phosphate. It is stored mainly in the liver where there
is oxidation to 4-pyridoxic acid and other inactive
metabolites which are excreted in the urine.
Purification Methods
Purify the vitamin by recrystallisation from EtOH/Me2CO, n-BuOH or MeOH/Et2O. Its solubility in H2O is 22%, and in EtOH it is 1.1%. It is insoluble in Et2O and CHCl3. Acidic aqueous solutions are stable at 120o/30minute. The free base has m 159-160o after recrystallisation from Me2CO and sublimation at 140-145o/0.0001mm. It has UV max at 290nm ( 84,000), 253 and 325nm ( 3,700 and 7,100) in 0.1N aqueous HCl. [Khua & Wendt Chem Ber 71 780 1938, 72 311 1939, Harris & Folkers J Am Chem Soc 61 1242 1939, Harris et al. J Am Chem Soc 62 3198 1940, Beilstein 21/5 V 492.]
Check Digit Verification of cas no
The CAS Registry Mumber 58-56-0 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 8 respectively; the second part has 2 digits, 5 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 58-56:
(4*5)+(3*8)+(2*5)+(1*6)=60
60 % 10 = 0
So 58-56-0 is a valid CAS Registry Number.
InChI:InChI=1/C8H11NO3.ClH/c1-5-8(12)7(4-11)6(3-10)2-9-5;/h2,10-12H,3-4H2,1H3;1H/p-1
58-56-0Relevant articles and documents
Biosynthesis of Vitamin B6: Incorporation of D-1-Deoxyxylulose
Hill, Robert E.,Sayer, Brian G.,Spenser, Ian D.
, p. 1916 - 1917 (1989)
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Method for environmentally friendly preparation of vitamin B6 and recycling of tail gas
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Paragraph 0042-0048; 0052-0055, (2019/07/04)
The invention relates to a method for environmentally friendly preparation of vitamin B6 and recycling of tail gas. The method comprises the following steps: carrying out a catalytic formylating reaction on carbon monoxide, hydrogen and 2-cyano-2-cis-butene-1,4-diol which is used as a starting material to prepare a 2-hydroxymethyl-3-cyano-4-hydroxy-n-butyraldehyde intermediate, condensing the intermediate with 2-aminopropionate or 2-aminopropionate hydrochloride, and carrying out salt formation to prepare the vitamin B6. The method does not use a 4-methyl-5-alkoxyoxazole intermediate that is expensive and generates a large amount of wastewater in the production process, and allows the tail gas to be recycled in synthesis of the starting raw material, so the method has the advantages of environmentally friendly process, high reaction selectivity, high product purity, high atom economy, and suitableness for the green industrial production of the vitamin B6.
A process for preparing vitamin B by the malic acid6 The method of
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, (2018/03/26)
The present invention relates to a method of using malic acid to prepare vitamin B6. The method comprises: using malic acid as a starting material; carrying out a hydroxymethylation reaction on the malic acid and formaldehyde in the presence of a basic catalyst to generate 2-hydroxy-2,3-dimethylol butanedioic acid; performing acid catalysis and lactonization for ring-forming to obtain 1H,4H-dihydrofuro[3,4-c]dihydrofuran-1,4-diketone (III); under base catalysis, condensing the obtained compound III and nitro ethane to obtain a compound IV; reducing the compound IV by using sodium borohydride or potassium borohydride to obtain a compound V; performing catalytic hydrogenation on the compound V to obtain a compound VI; and performing hydrolysis and ring-forming on the compound VI in an ethanol-hydrochloric acid system to obtain vitamin B6. According to the method of the present invention, the use of the 4-methyl-5-alkoxyl oxazole intermediate that is expensive and of which the preparation process causes pollution is avoid; the raw materials are inexpensive and readily available; the process is short; and the cost is low. The method in the present invention is simple in operation, less in wastewater discharge, highly environmentally friendly, and suitable for green industrial production of VB6.
Vitamin B6 Intermediate 4 - methyl - 5 - alkyl silicon oxygen radical wicked zuo, its preparation method and process for producing vitamin B6 The method of
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Paragraph 0068; 0069, (2017/08/25)
The invention relates to a vitamin B6 intermediate 4-methyl-5-alkylsiloxane oxazole, a preparation method thereof as well as a method for preparing the vitamin B6. 4-methyl-5-alkylsiloxane oxazole has the structure shown as the formula I. 2-alanine and formaldehyde or paraformaldehyde are subjected to N-hydroxymethylation and lactonization in a solvent under the action of an acid catalyst to obtain 4-methyl-tetrahydro-oxazole-5-ketone (II), the ketone is not separated and is directly subjected to chloro substitution, silicon etherification and an elimination reaction in the presence of an acid-binding agent to generate 4-methyl-5-alkylsiloxane oxazole (I). 4-methyl-5-alkylsiloxane oxazole and 2-n-propyl-1,3-dioxo-5-cycloheptene are subjected to addition and hydrolysis to prepare the vitamin B6. The process is short, the operation is easy, little wastewater is produced, safety and environmental protection are realized, the reaction selectivity is good, a product is low in cost and high in purity, and industrial production is facilitated better.
