595-29-9Relevant articles and documents
Synthesis of cyclic D-(+)-camphoric acid imides and study of their antiviral activity
Chernyshov, Vladimir V.,Yarovaya, Olga I.,Peshkov, Roman Yu.,Salakhutdinov, Nariman F.
, p. 763 - 768 (2020)
[Figure not available: see fulltext.] Several D-(+)-camphoric acid imides, not previously described in the literature, were synthesized with good yields. The synthesis of previously known imides was improved. The cytotoxicity and antiviral activity of all synthesized imides were studied.
Camphor acid acylhydrazone derivative as well as preparation method and application thereof (by machine translation)
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Paragraph 0046-0049, (2019/12/31)
The invention discloses a camphor acid-based acylhydrazone derivative and a preparation method thereof as, well as a preparation method and application of the derivative of the camphor acid-based acylhydrazone derivative (I) as shown: in the following formula (I). The derivative of, R (I) the present, invention is obtained by the, acylation of, camphor acid serving as a raw, 2,3 - material in, 2,6 - the, 2,4 - presence of camphor, 2,5 - acid as a raw material and, 3,4 - then dehydration to, 3,5 - obtain camphor acid, as a, raw material, and then acylation is. carried out with, hydrazine hydrate. NThe novel five-membered, heterocyclic camphor acid-based acylhydrazone derivatives can be used for synthesizing the novel five-membered heterocyclic camphor acid-based acylhydrazone derivatives as a novel; five-membered heterocyclic camphor acid-based acylhydrazone derivative in the catalysis of, an acid catalyst to form a novel five-membered, heterocyclic camphor acid,based acylhydrazone. derivative. (by machine translation)
Modified McFadyen-Stevens reaction for a versatile synthesis of aliphatic/aromatic aldehydes: Design, optimization, and mechanistic investigations
Iwai, Yuri,Ozaki, Takashi,Takita, Ryo,Uchiyama, Masanobu,Shimokawa, Jun,Fukuyama, Tohru
, p. 1111 - 1119 (2013/06/04)
The traditional McFadyen-Stevens reaction requires harsh alkaline reaction conditions, thus precluding application to the synthesis of aliphatic aldehydes. Our modified McFadyen-Stevens reaction enables the transformation from the N,N-acylsulfonyl hydrazine to the corresponding aldehyde upon treatment with an imidazole-TMS imidazole combination without relying on oxidative or reductive reagents. The reduced basicity and in situ protection of the resulting aldehyde widens the substrate scope to include aliphatic aldehydes, even ones bearing an α-hydrogen atom. Close examination of the side reactions for particular substrates in combination with theoretical considerations via DFT calculations led to a mechanistic understanding of the McFadyen-Stevens reaction involving an acyl diazene and a hydroxy carbene as reasonable intermediates.