603-45-2 Usage
Description
Rosolic acid, also known as Aurin, is a red crystalline or powdery substance derived from phenol or carbolic acid. It is soluble in alcohol and ether but insoluble in water. Rosolic acid possesses a range of chemical properties and applications, making it a versatile compound in various industries.
Uses
Used in Antioxidative Stress and DNA Fragmentation Inhibition:
Rosolic acid is used as an anti-oxidative stress agent and an inhibitor of DNA fragmentation, playing a crucial role in maintaining cellular integrity and preventing damage at the molecular level.
Used in Coloring and Photography Industry:
Rosolic acid serves as a red coloring medium in the coloring and photography industry. Its nonactinic property makes it safe for use in darkrooms, windows, and doorways. Additionally, it is mixed with water-soluble gums and applied as an antihalation layer on the backs of collodion and silver bromide gelatin plates.
Used as a pH Indicator:
Rosolic acid is utilized as a pH indicator, with a range from 5.0 to 6.8. This application is essential in various chemical and biological processes that require precise pH control.
Used in Dye Manufacturing:
Rosolic acid acts as an intermediate in the manufacturing of dyes, contributing to the production of a wide range of colored compounds used in various industries.
Used in Bacterial Isolation:
Rosolic acid finds application in the selective isolation of coliform bacteria, which is vital in the fields of microbiology and environmental science for the detection and analysis of specific bacterial strains.
Purification Methods
It forms green crystals with a metallic luster, but the colour depends on the solvent used. When recrystallised from brine (saturated aqueous NaCl) acidified with HCl, it forms red needles, but when recrystallised from EtO/AcOH, the crystals have a beetle iridescent green colour. It has been recrystallised from Me2CO (although it dissolves slowly), methyl ethyl ketone, 80-95% AcOH and from AcOH/*C6H6. An aqueous KOH solution is golden yellow, and a 70% H2SO4 solution is deep red in colour. An alternative purification is to dissolve this triphenylmethane dye in 1.5% of aqueous NH3, filter, and heat to 70-80o, then acidify with dilute AcOH by adding it slowly with vigorous stirring, whereby the aurin separates as a brick-red powder or as purplish crystals depending on the temperature and period of heating. Filter off the solid, wash it with H2O and a little dilute AcOH, then H2O again. Stir this solid with Et2O to remove any ketones and allow it to stand overnight in the Et2O, then filter and dry it in air then in a vacuum. [Gomberg & Snow J Am Chem Soc 47 202 1925, Baines & Driver J Chem Soc 123 1216 1923, UV: Burawoy Chem Ber 64 462 1941, Beilstein 8 IV 2646.]
Check Digit Verification of cas no
The CAS Registry Mumber 603-45-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,0 and 3 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 603-45:
(5*6)+(4*0)+(3*3)+(2*4)+(1*5)=52
52 % 10 = 2
So 603-45-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H14O3/c20-16-7-1-13(2-8-16)19(14-3-9-17(21)10-4-14)15-5-11-18(22)12-6-15/h1-12,20-21H
603-45-2Relevant articles and documents
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Baines,Driver
, p. 1216 (1923)
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Lability of the trifluoromethyl group of trifluoromethoxybenzenes under HF/Lewis acid conditions
Belter, Randolph K.
scheme or table, p. 1302 - 1307 (2011/02/22)
The trifluoromethyl functionality of trifluoromethoxybenzenes (trifluoromethyl phenyl ethers) becomes labile under HF/Lewis acid conditions. Substrates with an unsubstituted para-position shed their -CF3 groups while performing a Friedel-Crafts reaction upon another substrate molecule's trifluoromethoxy group to generate p-rosolic acids. Substrates that had blocking groups at the para-positions reacted ortho. The electron donating substituents methoxy and phenoxy interfered with the formation of rosolic acids.
Multiconstituent liquid lgG and IgM calibrators
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, (2008/06/13)
A serum in which are dissolved at least two heterologous antibodies, which are independently IgG or IgM and which specifically bind to different antigens, serves as a calibrator for multi-analyte immunoassays.