96255-87-7

Basic information

• Product Name: Thymidine, 5'-O-[tris[4-[(1,4-dioxopentyl)oxy]phenyl]methyl]-
• CAS NO: 96255-87-7
• Molecular Formula: C44H46N2O14
• Molecular Weight: 826.854
• Mol File: 96255-87-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Thymidine, 5'-O-[tris[4-[(1,4-dioxopentyl)oxy]phenyl]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Thymidine, 5'-O-[tris[4-[(1,4-dioxopentyl)oxy]phenyl]methyl]-(96255-87-7)
• EPA Substance Registry System: Thymidine, 5'-O-[tris[4-[(1,4-dioxopentyl)oxy]phenyl]methyl]-(96255-87-7)

Safety Data

• Hazardous Substances Data: 96255-87-7(Hazardous Substances Data)

Upstream product

• 408338-07-8 4,4',4''-Tris(levulinoyloxy)trityl bromide 
• 50-89-5 thymidine 
• 96255-85-5 4,4',4''-Tris(levulinoyloxy)tritanol 
• 96255-86-6 4-Hydroxy-4',4''-bis(levulinoyloxy)tritanol 
• 123-76-2 levulinic acid 
• 603-45-2 aurin 

Downstream Products

• 96255-88-8 S,S-Diphenyl 5'-O-<4,4',4''-tris(levulinoyloxy)trityl>thymidine 3'-phosphorodithioate 
• 70900-95-7 S,S-diphenyl thymidine 3'-phosphorodithioate 
• 76054-81-4 3'-O-(4,4'-dimethoxytrityl)thymidine 

Relevant articles and documents

4,4',4''-Tris(levulinoyloxy)trityl as a New Type of Primary Hydroxyl Protecting Group

The 4,4',4''-tris(levulinoxy)trityl (TLTr) group was introduced selectively on the 5'-oxygen of thymidine by use of in situ generated 4,4',4''-tris(levulinoyloxy)trityl bromide.The TLTr group was found to be sufficiently stable to acids and readily removed by hydrazinolysis followed by warming to 50 deg C in pyridine-acetic acid without damage of other protecting groups such as the O-acetyl and 4,4'-dimethoxytrityl groups.The utility of this new protecting group was demonstrated by the successful synthesis of thymidylyl(3'-5')thymidine where the TLTr group was employed as 5'-hydroxyl-protecting group.