607-66-9

Basic information

• Product Name: 2-HYDROXY-4-METHYLQUINOLINE
• Synonyms: 4-Methyl-2(1H)-quinolinone;4-Methyl-2-quinolone;4-Methylquinolin-2-one;Carbostyril, 4-methyl-;2-HYDROXYLEPIDINE;2-HYDROXY-4-METHYLQUINOLINE;4-METHYL-QUINOLIN-2-OL;4-METHYLCARBOSTYRIL
• CAS NO: 607-66-9
• Molecular Formula: C₁₀H₉NO
• Molecular Weight: 159.18
• EINECS: 210-139-0
• Mol File: 607-66-9.mol
• Article Data: 44

Chemical Properties

• Melting Point: 221-223 °C(lit.)
• Boiling Point: 284.68°C (rough estimate)
• Flash Point: 201.8ºC
• Appearance: /
• Density: 1.1202 (rough estimate)
• Vapor Pressure: 5.94E-05mmHg at 25°C
• Refractive Index: 1.6070 (estimate)
• Storage Temp.: 2-8°C
• PKA: 11.83±0.70(Predicted)
• BRN: 118331
• CAS DataBase Reference: 2-HYDROXY-4-METHYLQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-HYDROXY-4-METHYLQUINOLINE(607-66-9)
• EPA Substance Registry System: 2-HYDROXY-4-METHYLQUINOLINE(607-66-9)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-20/21/22
• Safety Statements: 26-37/39-22-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 607-66-9(Hazardous Substances Data)

Usage

Description

2-Hydroxy-4-methylquinoline is a quinolone compound that features a quinolin-2(1H)-one structure with a methyl group substitution at the 4th position. It is characterized by its white to light yellow crystal powder appearance.

Uses

Used in Pharmaceutical Industry:
2-Hydroxy-4-methylquinoline could be used as an intermediate in the synthesis of various pharmaceutical compounds for [application reason, e.g., treating bacterial infections or as a building block for developing new drugs].
Used in Chemical Research:
In the field of chemical research, 2-Hydroxy-4-methylquinoline might be utilized as a research compound for studying the properties and reactions of quinolone derivatives, potentially leading to the discovery of new chemical reactions or applications.
Used in Material Science:
2-Hydroxy-4-methylquinoline could be employed in material science as a component in the development of new materials with specific properties, such as luminescent materials or as part of sensor technologies.
[Please replace the placeholders [application reason] and the hypothetical uses with actual applications if they are provided in the source materials or known from other reliable sources.]

InChI:InChI=1/C10H9NO/c1-7-6-10(12)11-9-5-3-2-4-8(7)9/h2-6H,1H3,(H,11,12)

Upstream product

• 123-39-7 N-Methylformamide 
• 4053-40-1 4-methylquinoline 1-oxide 
• 4341-76-8 Ethyl 2-butynoate 
• 103-84-4 Acetanilid 
• 67-66-3 chloroform 
• 7732-18-5 water 
• 98-59-9 p-toluenesulfonyl chloride 
• 634-47-9 2-chloro-4-methylquinoline 
• 5234-26-4 N-(2-acetylphenyl)acetamide 
• 1462-03-9 1-methylcyclopentanol 
• 141-97-9 ethyl acetoacetate 
• 62-53-3 aniline 
• 102-01-2 N-phenylacetoacetamide 
• 119112-48-0 3,3-bis-benzylsulfanyl-butyric acid anilide 

Downstream Products

• 634-47-9 2-chloro-4-methylquinoline 
• 491-35-0 C₆H₄NCH₂CHCCH₂ 
• 64658-04-4 2-bromo-4-methyl-quinoline 
• 90771-17-8 4-methyl-6-nitro-quinolin-2-ol 
• 4437-65-4 4-methyl-2-thioxo-1H-quinoline 
• 128128-28-9 1-allyl-4-methyl-2-quinolone 
• 185505-21-9 2-allyloxy-4-methylquinoline 
• 607-66-9 4-methylquinolin-2-ol 
• 15113-00-5 2-methoxy-4-methyl quinoline 
• 817166-24-8 2-ethylsulfanyl-4-methyl-quinoline 
• 10562-04-6 4-methyl-N-phenylquinolin-2-amine 
• 1315337-06-4 4-methyl-2-(pentafluorophenyl)quinoline 
• 5465-88-3 4-methylquinolin-2-yl 4-methylbenzenesulfonate 
• 19069-84-2 4-methyl-3-phenylquinolin-2(1H)-one 

Relevant articles and documents

A facile synthesis of novel 9-methyl[1,2,3]selenadiazoles[4,5-b]quinoline and 9-methyl[1,2,3]thiadiazole[4,5-b]quinoline as a new class of antimicrobial agents

2-chloro-4-methyl quinoline 2 on condensation with semicarbazide hydrochloride gave its semicarbazone. This on reaction with SeO2 and SOCl2 yielded a new class of novel selenadiazoles 4 and thiadiazoles 5, respectively. The structure of all the compounds were elucidated on the basis of elemental analysis, IR, 1H NMR, and the mass spectral data. Some derivatives of 9-methyl[1,2,3]selenadiazole[4,5-b] quinoline and 9-methyl[1,2,3]thiadiazole [4,5-b]quinoline have been screened for antimicrobial activities. Copyright Taylor & Francis Group, LLC.

A facile and versatile electro-reductive system for hydrodefunctionalization under ambient conditions

A general electrochemical system for reductive hydrodefunctionalization is described, employing the inexpensive and easily available triethylamine (Et3N) as a sacrificial reductant. This protocol is characterized by facile operation, sustainable conditions, and exceptionally wide substrate scope covering the cleavage of C-halogen, N-S, N-C, O-S, O-C, C-C and C-N bonds. Notably, the selectivity and capability of reduction can be conveniently switched by simple incorporation or removal of an alcohol as a co-solvent.

Efficient visible light mediated synthesis of quinolin-2(1H)-ones from quinolineN-oxides

Quinolin-2(1H)-ones are one of the important classes of compounds due to their prevalence in natural products and in pharmacologically useful compounds. Here we present an unconventional and hitherto unknown photocatalytic approach to their synthesis from easily available quinoline-N-oxides. This reagent free highly atom economical photocatalytic method, with low catalyst loading, high yield and no undesirable by-product, provides an efficient greener alternative to all conventional synthesis reported to date. The robustness of the methodology has been successfully demonstrated with easy scaling up to the gram scale.