61-28-9

Basic information

• Product Name: 1-ethyl-1,3-dihydro-2H-indol-2-one
• Synonyms: 2H-Indol-2-one, 1-ethyl-1,3-dihydro-; 1-Ethyl-2-indolinone; 1-Ethyloxindole; 2-Indolinone, 1-ethyl-; Ba 2778; N-Ethyloxindole; NSC 8893; 1-Ethyl-1,3-dihydro-2H-indol-2-one
• CAS NO: 61-28-9
• Molecular Formula: C₁₀H₁₁NO
• Molecular Weight: 161.2004
• EINECS: 200-503-7
• Mol File: 61-28-9.mol
• Article Data: 33

Chemical Properties

• Boiling Point: 352.6°C at 760 mmHg
• Flash Point: 172.9°C
• Density: 1.122g/cm³
• Vapor Pressure: 3.8E-05mmHg at 25°C
• Refractive Index: 1.565
• CAS DataBase Reference: 1-ethyl-1,3-dihydro-2H-indol-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-ethyl-1,3-dihydro-2H-indol-2-one(61-28-9)
• EPA Substance Registry System: 1-ethyl-1,3-dihydro-2H-indol-2-one(61-28-9)

Safety Data

• Hazardous Substances Data: 61-28-9(Hazardous Substances Data)

Usage

Description

1-Ethyl-1,3-dihydro-2H-indol-2-one, also known as 1-Ethyl-1,3-dihydroindol-2-one, is a chemical compound characterized by the molecular formula C10H11NO. It is a colorless to pale yellow liquid with a floral, sweet, and slightly fruity odor, which makes it a versatile ingredient in various industries.

Uses

Used in Cosmetics Industry:
1-Ethyl-1,3-dihydro-2H-indol-2-one is used as a fragrance and flavoring agent for its pleasant and appealing scent, enhancing the sensory experience of perfumes, soaps, and lotions.
Used in Food Industry:
In the food industry, 1-Ethyl-1,3-dihydro-2H-indol-2-one is used as a flavoring agent to impart a pleasant aroma and taste to a variety of food products, including beverages, confections, and baked goods.
Used in Pharmaceutical Research:
1-Ethyl-1,3-dihydro-2H-indol-2-one is being studied for its potential therapeutic applications, such as anti-inflammatory and analgesic properties, indicating its possible use as a pharmaceutical agent. However, further research is required to fully understand its pharmacological effects and safety profile.

Upstream product

• 39086-61-8 2-chloro-N-ethylacetanilide 
• 142612-52-0 N-ethyl-N-phenyl-α-(methoxycarbonyl)-α-diazoacetamide 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 75-04-7 ethylamine 
• 18698-97-0 ortho-bromophenylacetic acid 
• 1399215-04-3 diethyl 1-ethyl-2-oxoindolin-3-yl phosphate 
• 157837-30-4 bromo-acetic acid-(N-ethyl-anilide) 
• 76269-81-3 2-diazo-N-ethyl-N-phenylacetamide 
• 10604-59-8 N-Ethylindole 
• 5059-30-3 2-chloroindole-3-carboxaldehyde 
• 91-56-5 indole-2,3-dione 
• 103-69-5 N-ethyl-N-phenylamine 
• 79-04-9 chloroacetyl chloride 
• 69564-74-5 1-vinylindoline-2,3-dione 

Downstream Products

• 50793-70-9 1-ethyl-3-(4-dimethylamino-benzylidene)-indolin-2-one 
• 110554-77-3 1-ethyl-3-(4-diethylamino-phenylimino)-indolin-2-one 
• 141210-65-3 1-ethyl-(N,N-dimethyl)aminomethylene-2,3-dihydro-2-indolinoone 
• 141210-66-4 trans-1-ethyl-3-(dimethylaminomethylene)oxindole 
• 122767-35-5 1-ethyl-3,3-bis-(4-methoxy-phenyl)-indolin-2-one 

Relevant articles and documents

Photochemical 1,3-migration of the hydroxyl group in 1-alkyl-3-hydroxyoxindoles

Irradiation of 1-alkyl-3-hydroxyoxindoles in degassed solutions afforded 1-alkyl-4-hydroxyoxindoles via 1,3-migration of the hydroxyl group together with 1-alkyloxindoles.

New donor-π-acceptor type triazatruxene derivatives for highly efficient dye-sensitized solar cells

A new class of organic dyes based on triazatruxene have been designed and synthesized for dye-sensitized solar cells. The photoelectronic properties of these donor-π-acceptor dyes can be tuned by changing π-conjugated linkers. The best performance was found for triazatruxene dye TD1, wherein, with thiophene as the conjugated linker and cyanoacrylic acid as the acceptor, a power conversion efficiency up to 6.10% was achieved.

Synthesis and Exploration of Abscisic Acid Receptor Agonists Against Dought Stress by Adding Constraint to a Tetrahydroquinoline-Based Lead Structure

New oxotetrahydroquinolinyl- and oxindolinyl sulfonamides interacting with RCAR/(PYR/PYL) receptor proteins were identified as lead structures against drought stress in crops starting from protein docking studies of a sulfonamide lead structure, followed by in-depth SAR studies. Optimized five to six step synthetic approaches via substituted amino oxo-tetrahydro-quinolines and amino oxo-indolines as essential intermediates gave access to the envisaged oxo-tetrahydroquinolinyl and oxindolinyl sulfonamides. Whilst oxo-tetrahydroquinolinyl sulfonamides with additional carbon substituents or spiro-cycloalkyl groups exhibited only low to moderate target affinities, the corresponding spiro-oxindolinyl and oxo-tetrahydroquinolinyl sulfonamides carrying optimized N-substituents revealed strong interactions with RCAR/(PYR/PYL) receptor proteins in Arabidopsis thaliana. Remarkably, the in vitro activity observed for these new compounds was on the same level as observed for the naturally occurring plant hormone in line with strong efficacy against drought stress in-vivo (canola and wheat as broad-acre crops).

Annulation reaction of cyclic pyridinium ylides with: In situ generated azoalkenes for the construction of spirocyclic skeletons

Two new types of cyclic pyridinium ylides were designed and further used in reactions with azoalkenes to access structurally diverse spirocyclic compounds. A range of spiropyrazoline oxindoles could be smoothly obtained in up to 99% yield via a [4 + 1] annulation process with oxindole 3-pyridinium ylides as C1 synthons. Similarly, a series of spiropyrazoline indanones could be prepared with indanone 2-pyridinium ylides as C1 synthons. This work represents the first example of cyclic pyridinium ylides as C1 synthons for the efficient construction of spirocyclic compounds.