610-96-8Relevant articles and documents
Oxidative Coupling of Aldehydes with Alcohol for the Synthesis of Esters Promoted by Polystyrene-Supported N-Heterocyclic Carbene: Unraveling the Solvent Effect on the Catalyst Behavior Using NMR Relaxation
Di Carmine, Graziano,Ragno, Daniele,Massi, Alessandro,D'agostino, Carmine
, p. 4927 - 4931 (2020)
Heterogeneous organocatalysts hold great potential as they offer practical advantages in terms of purification and reusability compared with the homogeneous counterpart. A puzzling aspect is the solvent effect on their catalytic performance. Here we propo
Scalable On-Demand Production of Purified Diazomethane Suitable for Sensitive Catalytic Reactions
Sheeran, Jillian W.,Campbell, Kiersten,Breen, Christopher P.,Hummel, Gerald,Huang, Changfeng,Datta, Anamika,Boyer, Serge H.,Hecker, Scott J.,Bio, Matthew M.,Fang, Yuan-Qing,Ford, David D.,Russell, M. Grace
supporting information, p. 522 - 528 (2021/02/03)
We have developed a convenient development-scale reactor (0.44 mol/h) to prepare diazomethane from N-methyl-N-nitroso-p-toluenesulfonamide (MNTS) in ~80% yield. Diazomethane (CH2N2) made with this reactor is extracted into nitrogen gas from the liquid reaction mixture, effectively removing it from reagents and byproducts that may interfere in subsequent reactions. Vertically oriented tubular reactors were used to produce and consume diazomethane in situ. Key features of this reactor include high productivity and correspondingly low reactor volume (reactor volume/liquid flow rate = 6.5 min) and a commercially available gas/liquid separator equipped with a selectively permeating hydrophilic membrane. The design of the reactor keeps the inventory below 53 mg of CH2N2 during normal operation. The reactor was demonstrated by generating CH2N2 that was used in a connected continuous reactor. We evaluated esterification reactions and a continuous Pd-catalyzed cyclopropanation reaction with the reactor and achieved high conversion with 1.5 and 4.1 equiv of MNTS precursor, respectively.
Preparation method of methyl benzoate compound
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Paragraph 0019; 0037-0038, (2021/08/14)
A preparation method of a methyl benzoate compound comprises the step that the methyl benzoate compound is prepared by carrying out esterification reaction on a benzoic acid compound and methyl alcohol under the catalysis of dihalogen hydantoin, and the molar ratio of the benzoic acid compound to the dihalogen hydantoin to the methyl alcohol is 1: (0.01-0.4): (2-30). According to the preparation method, the methyl benzoate compound can be efficiently prepared under mild conditions, the operation is safe, no acid waste liquid exists, meanwhile, raw materials are easy to obtain, and the production cost is low.