6277-67-4Relevant articles and documents
Nanofiltration-Enabled In Situ Solvent and Reagent Recycle for Sustainable Continuous-Flow Synthesis
Fodi, Tamas,Didaskalou, Christos,Kupai, Jozsef,Balogh, Gyorgy T.,Huszthy, Peter,Szekely, Gyorgy
, p. 3435 - 3444 (2017)
Solvent usage in the pharmaceutical sector accounts for as much as 90 % of the overall mass during manufacturing processes. Consequently, solvent consumption poses significant costs and environmental burdens. Continuous processing, in particular continuou
Exploring the copper binding ability of Mets7 hCtr-1 protein domain and His7 derivative: An insight in Michael addition catalysis
Rimoldi, Isabella,Bucci, Raffaella,Feni, Lucia,Santagostini, Laura,Facchetti, Giorgio,Pellegrino, Sara
, (2020/10/26)
Mets7 is a methionine-rich motif present in hCtr-1 transporter that is involved in copper cellular trafficking. Its ability to bind Cu(I) was recently exploited to develop metallopeptide catalysts for Henry condensation. Here, the catalytic activity of Me
Synthesis, properties and reactivity of BCl2 aza-BODIPY complexes and salts of the aza-dipyrrinato scaffold
Burke, Luke,Diaz-Rodriguez, Roberto M.,Robertson, Katherine N.,Thompson, Alison
, p. 2139 - 2147 (2020/03/27)
The synthesis and characterisation of the BCl2-chelated complexes of both archetypal aza-dipyrrin sub-Types are presented. A stepwise halogen exchange, leading to a mixed-halide Cl-B-F intermediate, is implicated in the conversion of F-Aza-BODIPYs to Cl-Aza-BODIPYs upon treatment with BCl3. The utility of the Cl-Aza-BODIPY scaffold to facilitate substitutions at boron is demonstrated under mild conditions through treatment with aryl Grignard reagents. Additionally, the lability of the B-Cl bond enables facile removal of the BCl2 group, i.e. deprotection of F-Aza-BODIPYs, under aqueous conditions. Three aza-dipyrrin HX salts were also synthesised and characterised. The pKa of the protonated aza-dipyrrin was determined to be 4, thereby providing insight regarding the storage and stability of such species.
1,2,4-Triphenylpyrroles: Synthesis, Structure and Luminescence Properties
Ferreira, Joana R. M.,Guieu, Samuel,Nunes Da Silva, Raquel,Rocha, Jo?o,Silva, Artur M. S.
, p. 632 - 634 (2020/03/27)
Pyrroles are widely found in natural products and play an important role in biological processes. Certain pyrrole derivatives are fluorescent and may be used as molecular probes or biomarkers in the diagnosis of diseases, such as Alzheimer's or Parkinson'