685508-11-6

Basic information

• Product Name: 3-Oxazolidinecarboxylic acid, 5-[[[(1S)-1-(methoxycarbonyl)-3-methylbutyl]amino]carbonyl]-2,2-dimeth yl-4-(phenylmethyl)-, 1,1-dimethylethyl ester, (4R,5S)-
• CAS NO: 685508-11-6
• Molecular Formula: C25H38N2O6
• Molecular Weight: 462.587
• Mol File: 685508-11-6.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-Oxazolidinecarboxylic acid, 5-[[[(1S)-1-(methoxycarbonyl)-3-methylbutyl]amino]carbonyl]-2,2-dimeth yl-4-(phenylmethyl)-, 1,1-dimethylethyl ester, (4R,5S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Oxazolidinecarboxylic acid, 5-[[[(1S)-1-(methoxycarbonyl)-3-methylbutyl]amino]carbonyl]-2,2-dimeth yl-4-(phenylmethyl)-, 1,1-dimethylethyl ester, (4R,5S)-(685508-11-6)
• EPA Substance Registry System: 3-Oxazolidinecarboxylic acid, 5-[[[(1S)-1-(methoxycarbonyl)-3-methylbutyl]amino]carbonyl]-2,2-dimeth yl-4-(phenylmethyl)-, 1,1-dimethylethyl ester, (4R,5S)-(685508-11-6)

Safety Data

• Hazardous Substances Data: 685508-11-6(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 685508-06-9 O-[(3R)-tert-butoxycarbonylamino-(2S)-hydroxy-2,3-isopropylidene-4-phenylbutanoyl]-(1'R,2'S,5'R)-8'-phenylmenthol 
• 640279-64-7 O-[(3R)-tert-butoxycarbonylamino-(2S)-hydroxy-4-phenylbutanoyl]-(1'R,2'S,5'R)-8'-phenylmenthol 
• 640279-63-6 O-[(2S)-hydroxy-(3R)-3-nitro-4-phenylbutanoyl]-(1'R,2'S,5'R)-8'-phenylmenthol 
• 6125-24-2 2-Phenylnitroethane 
• 2666-93-5 (S)-Leu-OMe 
• 139397-07-2 (4R,5S)-4-benzyl-3-[(tert-butoxy)carbonyl]-2,2-dimethyl-1,3-oxazolidine-5-carboxylic acid 

Downstream Products

• 65391-42-6 Bestatin hydrochloride 
• 65322-89-6 methyl (2S)-2-(((2S,3R)-3-amino-2-hydroxy-4-phenylbutanoyl)amino)-4-methylpentanoate 

Relevant articles and documents

Asymmetric Nitroaldol Reaction. Synthesis of Taxotere Side Chain and (-)-Bestatin Using (1R)-8-Phenylmenthyl Glyoxylate

The nitroaldol reaction of (1R)-8-phenylmenthyl glyoxylate (3b) with 1-nitro-1-phenylmethane (4) or with 1-nitro-2-phenylethane (13) led stereoselectively to adducts syn-2b and syn-12b, which were then transformed into the Taxotere side chain and (-)-best