69502-27-8 Usage
Description
Heptaethylene glycol di(p-toluenesulfonate), also known as Tos-PEG8-Tos, is a PEG linker containing two tosyl groups. It is characterized by a hydrophilic PEG spacer that enhances solubility in aqueous media, and the tosyl group serves as an excellent leaving group for nucleophilic substitution reactions.
Uses
Used in Chemical Synthesis:
Heptaethylene glycol di(p-toluenesulfonate) is used as a PEG linker for increasing solubility in aqueous media and facilitating nucleophilic substitution reactions. The hydrophilic PEG spacer improves the solubility of molecules in water, while the tosyl group acts as a good leaving group, making it easier for nucleophiles to attack and form new bonds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Heptaethylene glycol di(p-toluenesulfonate) is used as a versatile building block for the synthesis of various drug candidates. The PEG linker can be used to improve the solubility, stability, and bioavailability of drugs, while the tosyl group can be utilized in the synthesis of complex molecular structures.
Used in Bioconjugation:
Heptaethylene glycol di(p-toluenesulfonate) is used as a bioconjugation agent to attach biologically active molecules, such as proteins, peptides, or other biomolecules, to a PEG backbone. The tosyl group's reactivity allows for efficient coupling, while the PEG spacer provides stability and solubility in aqueous environments.
Used in Drug Delivery Systems:
In drug delivery systems, Heptaethylene glycol di(p-toluenesulfonate) is used as a component in the design of targeted drug carriers. The PEG linker can be functionalized with targeting ligands, while the tosyl group can be used to attach drug molecules, enabling the development of targeted therapies with improved efficacy and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 69502-27-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,9,5,0 and 2 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 69502-27:
(7*6)+(6*9)+(5*5)+(4*0)+(3*2)+(2*2)+(1*7)=138
138 % 10 = 8
So 69502-27-8 is a valid CAS Registry Number.
69502-27-8Relevant articles and documents
Synergistic covalent-and-supramolecular polymers connected by [2]pseudorotaxane moieties
Liu, Kai,Qi, Yumeng,Wan, Junjun,Wang, Yongming,Yan, Xuzhou,Yu, Chunyang,Zhang, Xinhai,Zhang, Zhaoming,Zhao, Jun
supporting information, p. 7374 - 7377 (2021/08/03)
Synergistic covalent-and-supramolecular polymers, in which covalent polymers and supramolecular polymers connect with each other through [2]pseudorotaxane moieties, are designed and synthesized. The unique topological structure effectively enhances the sy
Efficient synthesis of Hsp90 inhibitor dimers as potential antitumor agents
Sekiguchi, Hironori,Muranaka, Kazuhiro,Osada, Akiko,Ichikawa, Satoshi,Matsuda, Akira
experimental part, p. 5732 - 5737 (2010/09/11)
The PU-H58-dimers 13a-15b were efficiently synthesized and their biological properties were evaluated. The copper-catalyzed alkyne azide coupling was effective in simultaneously linking three components via a triazole formation to afford the target dimers
Synthesis and properties of ABA amphiphiles
Chen, Yiyan,Baker, Gregory L.
, p. 6870 - 6873 (2007/10/03)
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