922527-86-4Relevant articles and documents
Effect of crown ether ring size on binding and fluorescence response to saxitoxin in anthracylmethyl monoazacrown ether chemosensors
Mao, Hua,Thorne, John B.,Pharr, Jennifer S.,Gawley, Robert E.
, p. 1273 - 1279 (2006)
Convenient macrocyclization synthetic routes for the preparation of different-sized monoaza anthracylmethyl crown ether chemosensors (15-crown-5, 18-crown-6, 21-crown-7, 24-crown-8, and 27-crown-9) are described. Evaluation of these crowns as chemosensors for saxitoxin revealed that the larger crowns have moderately higher binding constants, with the 27-crown-9 chemosensor having the largest binding constant (2.29 × 105 (mol/L)-1). Fluorescence enhancements of 100% were observed at saxitoxin concentrations of 5 μmol/L, which is close to the detection limit in mouse bioassay.