705-44-2

Basic information

• Product Name: 3-TRIFLUOROMETHOXYTOLUENE
• Synonyms: m-(Trifluoromethoxy)toluene;m-Tolyl trifluoromethyl ether;3-Methylphenyl trifluoromethyl ether
• CAS NO: 705-44-2
• Molecular Formula: C₈H₇F₃O
• Molecular Weight: 176.14
• Mol File: 705-44-2.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 136.4 °C at 760 mmHg
• Flash Point: 42.1 °C
• Appearance: /
• Density: 1.205g/cm³
• Vapor Pressure: 9.15mmHg at 25°C
• Refractive Index: 1.436
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3-TRIFLUOROMETHOXYTOLUENE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-TRIFLUOROMETHOXYTOLUENE(705-44-2)
• EPA Substance Registry System: 3-TRIFLUOROMETHOXYTOLUENE(705-44-2)

Safety Data

• Hazardous Substances Data: 705-44-2(Hazardous Substances Data)

Usage

General Description

3-Trifluoromethoxytoluene is a chemical compound with the molecular formula C8H7F3O. It is a colorless liquid that is used as an intermediate in the production of pharmaceuticals, agrochemicals, and other organic compounds. Its main function is as a building block for the synthesis of various organic chemicals and has applications in the manufacturing of specialty chemicals. It is considered to be stable under normal conditions and is not known to have any harmful effects on human health or the environment. However, it should be handled with care and in accordance with proper safety protocols due to its potential for irritancy and flammability.

InChI:InChI=1/C8H7F3O/c1-6-3-2-4-7(5-6)12-8(9,10)11/h2-5H,1H3

Upstream product

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Relevant articles and documents

Photocatalytic trifluoromethoxylation of arenes and heteroarenes in continuous-flow

The first example of photocatalytic trifluoromethoxylation of arenes and heteroarenes under continuous-flow conditions is described. Application of continuous-flow microreactor technology allowed to reduce the residence time up to 16 times in comparison t

Redox-Active Reagents for Photocatalytic Generation of the OCF3 Radical and (Hetero)Aryl C?H Trifluoromethoxylation

The trifluoromethoxy (OCF3) radical is of great importance in organic chemistry. Yet, the catalytic and selective generation of this radical at room temperature and pressure remains a longstanding challenge. Herein, the design and development of a redox-active cationic reagent (1) that enables the formation of the OCF3 radical in a controllable, selective, and catalytic fashion under visible-light photocatalytic conditions is reported. More importantly, the reagent allows catalytic, intermolecular C?H trifluoromethoxylation of a broad array of (hetero)arenes and biorelevant compounds. Experimental and computational studies suggest single electron transfer (SET) from excited photoredox catalysts to 1 resulting in exclusive liberation of the OCF3 radical. Addition of this radical to (hetero)arenes gives trifluoromethoxylated cyclohexadienyl radicals that are oxidized and deprotonated to afford the products of trifluoromethoxylation.

O-Trifluoromethylation of Phenols: Access to Aryl Trifluoromethyl Ethers by O-Carboxydifluoromethylation and Decarboxylative Fluorination

A new strategy for the synthesis of aryl trifluoromethyl ethers (ArOCF3) by combining O-carboxydifluoromethylation of phenols and subsequent decarboxylative fluorination is reported. This protocol allows easy construction of functionalized trifluoromethoxybenzenes and trifluoromethylthiolated arenes (ArSCF3) in moderate to good yields. Moreover, it utilizes accessible and inexpensive reagents sodium bromodifluoroacetate and SelectFluor II and, thus, is practical for O-trifluoromethylation of phenols. The potential application of this method is demonstrated with the preparation of a plant-growth regulator, Flurprimidol.