70714-83-9

Basic information

• Product Name: [4-(phenylsulphonyl)phenyl]hydrazine
• Synonyms: [4-(phenylsulphonyl)phenyl]hydrazine;[4-(Phenylsulfonyl)phenyl]hydrazine;(4-benzenesulfonyl-phenyl)-hydrazine
• CAS NO: 70714-83-9
• Molecular Formula: C₁₂H₁₂N₂O₂S
• Molecular Weight: 248.30088
• EINECS: 274-808-9
• Mol File: 70714-83-9.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 475.3°C at 760 mmHg
• Flash Point: 241.2°C
• Appearance: /
• Density: 1.346g/cm³
• Vapor Pressure: 3.37E-09mmHg at 25°C
• Refractive Index: 1.653
• PKA: 3.88±0.20(Predicted)
• CAS DataBase Reference: [4-(phenylsulphonyl)phenyl]hydrazine(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(phenylsulphonyl)phenyl]hydrazine(70714-83-9)
• EPA Substance Registry System: [4-(phenylsulphonyl)phenyl]hydrazine(70714-83-9)

Safety Data

• Hazardous Substances Data: 70714-83-9(Hazardous Substances Data)

Usage

Description

[4-(phenylsulphonyl)phenyl]hydrazine, with the chemical formula C12H12N2O2S, is a hydrazine derivative featuring a hydrazine group (NH-NH) attached to a phenylsulphonylphenyl group. [4-(phenylsulphonyl)phenyl]hydrazine is recognized for its diverse biological activities, including anti-tubercular, anti-inflammatory, and anti-cancer properties. Its potential in treating neurodegenerative diseases and its structural properties make it a promising candidate for pharmaceutical development, offering therapeutic benefits across various medical applications.

Uses

Used in Pharmaceutical Industry:
[4-(phenylsulphonyl)phenyl]hydrazine is used as a pharmaceutical compound for its anti-tubercular, anti-inflammatory, and anti-cancer properties. Its ability to target and combat tuberculosis, reduce inflammation, and inhibit cancer cell growth makes it a valuable asset in the development of new medications.
Used in Neurodegenerative Disease Treatment:
In the field of neurology, [4-(phenylsulphonyl)phenyl]hydrazine is used as a potential therapeutic agent for neurodegenerative diseases. Its structure and properties allow it to be studied for its effectiveness in treating conditions such as Alzheimer's, Parkinson's, and other related disorders, offering hope for improved patient outcomes and quality of life.
Used in Drug Development:
[4-(phenylsulphonyl)phenyl]hydrazine is utilized as a key component in drug development, thanks to its diverse biological activities and potential therapeutic benefits. Researchers and pharmaceutical companies are exploring its use in creating new drugs that can address a wide range of medical conditions, from infectious diseases to cancer and neurodegenerative disorders.

InChI:InChI=1/C12H12N2O2S/c13-14-10-6-8-12(9-7-10)17(15,16)11-4-2-1-3-5-11/h1-9,14H,13H2

Upstream product

• 71-43-2 benzene 
• 121-57-3 4-aminobenzene sulfonic acid 
• 33597-50-1 4-Trifluoracetamino-diphenylsulfon 
• 7019-01-4 p-aminophenyl phenyl sulfone 
• 80-00-2 4-Chlorophenyl phenyl sulfone 
• 7803-57-8 hydrazine hydrate 
• 23038-36-0 1-bromo-4-(phenylsulphonyl)benzene 

Downstream Products

• 100136-61-6 N-(4-benzenesulfonyl-phenyl)-N'-sulfinyl-hydrazine 
• 16600-02-5 3-methyl-3H-benzothiazol-2-one (4-benzenesulfonyl-phenyl)-hydrazone 

Relevant articles and documents

Aggregation-induced emission and intermolecular charge transfer effect in triphenylamine fluorophores containing diphenylhydrazone structures

Three new chromophores incorporating acceptor-π-donor-π-acceptor structural motifs and mono-, di- and tri-branched diphenylsulfone base linked to triphenylamine through a hydrazone π-bridge were synthesized, and the photoluminescence properties of the three chromophores were studied in solutions as well as in aggregated states. All the fluorophores emitted strong blue fluorescence in THF. Mono- and di-branched triphenylamine both exhibited increasing blue fluorescence and displayed an AIEE effect in the aggregated state. Tri-branched triphenylamine emitted green fluorescence and presented the AIE effect in the aggregated state. These interesting phenomena have been interpreted by a molecular stacking mode with molecular dynamics (MD) and DFT calculations. The unique propeller shaped molecular configuration of triphenylamine prevented face to face π-π stacking and induced the hindered rotation, which resulted in the AIEE or AIE effect in the aggregated state. The enlarged coplanarity of diphenylhydrazone chains increased the conjugation of tri-branched triphenylamine, which was beneficial to the formation of ICT and AIE and resulted in emitting green ICT fluorescence in the aggregated state. Fluorescent microscope imaging and the fluorescent pictures of the powder states certified the strong AIEE effect or AIE effect in the solid.

1,2,3,4,5,6-Hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position

The present invention discloses radioligands of 9-arylsulfone of the formula (X) or a pharmaceutically acceptable salt or enantiomer thereof, which are useful in diagnosing depression, obesity and other CNS disorders.

1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles containing arylsulfones at the 9-position

The present invention are substituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (X) and unsubstituted 9-arylsulfone-1,2,3,4,5,6-hexahydroazepino[4,5-b]indoles (XI) such as the compound of EXAMPLE 13 which are useful in treating depression, obesity and other CNS disorders.