709-69-3

Basic information

• Product Name: Benzoic acid, 4-(fluorocarbonyl)-, methyl ester (9CI)
• Synonyms: Benzoic acid, 4-(fluorocarbonyl)-, methyl ester (9CI)
• CAS NO: 709-69-3
• Molecular Formula: C₉H₇FO₃
• Molecular Weight: 182.1484832
• Product Categories: ACIDHALIDE
• Mol File: 709-69-3.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzoic acid, 4-(fluorocarbonyl)-, methyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-(fluorocarbonyl)-, methyl ester (9CI)(709-69-3)
• EPA Substance Registry System: Benzoic acid, 4-(fluorocarbonyl)-, methyl ester (9CI)(709-69-3)

Safety Data

• Hazardous Substances Data: 709-69-3(Hazardous Substances Data)

Upstream product

• 7377-26-6 4-Methoxycarbonylbenzoyl chloride 
• 1571-08-0 methyl 4-formylbenzoate 
• 1679-64-7 Monomethyl terephthalate 

Downstream Products

• 171364-80-0 methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate 
• 1129-35-7 4-cyanobenzoic acid methyl ester 
• 1616766-87-0 methyl 4-((triisopropylsilyl)ethynyl)benzoate 
• 42497-80-3 methyl 4-(phenylethynyl)benzoate 
• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 65488-27-9 (4-carbomethoxyphenyl)trimethylstannane 
• 905966-40-7 methyl 4-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)benzoate 
• 729-17-9 methyl 4-(4'-methoxyphenyl)benzoate 
• 71616-84-7 4-methoxycarbonyl-4'-methoxybenzophenone 
• 1325725-67-4 (R)-methyl 4-(2-oxo-3-phenyltetrahydrofuran-3-yl)carbonyl benzoate 

Relevant articles and documents

Rapid and column-free syntheses of acyl fluorides and peptides usingex situgenerated thionyl fluoride

Thionyl fluoride (SOF2) was first isolated in 1896, but there have been less than 10 subsequent reports of its use as a reagent for organic synthesis. This is partly due to a lack of facile, lab-scale methods for its generation. Herein we report a novel protocol for theex situgeneration of SOF2and subsequent demonstration of its ability to access both aliphatic and aromatic acyl fluorides in 55-98% isolated yields under mild conditions and short reaction times. We further demonstrate its aptitude in amino acid couplings, with a one-pot, column-free strategy that affords the corresponding dipeptides in 65-97% isolated yields with minimal to no epimerization. The broad scope allows for a wide range of protecting groups and both natural and unnatural amino acids. Finally, we demonstrated that this new method can be used in sequential liquid phase peptide synthesis (LPPS) to afford tri-, tetra-, penta-, and decapeptides in 14-88% yields without the need for column chromatography. We also demonstrated that this new method is amenable to solid phase peptide synthesis (SPPS), affording di- and pentapeptides in 80-98% yields.

CsF-Catalyzed Fluoroacylation of Tetrafluoroethylene Using Acyl Fluorides for the Synthesis of Pentafluoroethyl Ketones

A catalytic method for the synthesis of pentafluoroethyl ketones has been developed. The cesium fluoride catalyst can be used to convert acyl fluorides into the pentafluoroethyl ketones under tetrafluoroethylene pressure without generating stoichiometric

METHOD AND REAGENT FOR DEOXYFLUORINATION

A safe, simple, and selective method and reagent for deoxyfluorination is disclosed. With the method and reagent disclosed herein, organic compounds such as carboxylic acids, carboxylates, carboxylic acid anhydrides, aldehydes, and alcohols can be fluorinated by using the most common nucleophilic fluorinating reagents and electron deficient fluoroarenes as mediators under mild conditions, giving corresponding fluoroorganic compounds in excellent yield with a wide range of functional group compatibility and easy product purification. For example, directly utilizing KF for deoxyfluorination of carboxylic acids provides the most economical and the safest pathway to access acyl fluorides, key intermediates for syntheses of peptide, amide, ester, and dry fluoride salts.