74670-68-1

Basic information

• Product Name: 1-(2,2-difluorovinyl)-4-(trifluoromethyl)benzene
• Synonyms: 1-(2,2-difluorovinyl)-4-(trifluoromethyl)benzene
• CAS NO: 74670-68-1
• Molecular Weight: 208.131
• Mol File: 74670-68-1.mol
• Article Data: 19

Chemical Properties

• CAS DataBase Reference: 1-(2,2-difluorovinyl)-4-(trifluoromethyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2-difluorovinyl)-4-(trifluoromethyl)benzene(74670-68-1)
• EPA Substance Registry System: 1-(2,2-difluorovinyl)-4-(trifluoromethyl)benzene(74670-68-1)

Safety Data

• Hazardous Substances Data: 74670-68-1(Hazardous Substances Data)

Upstream product

• 349-95-1 4-(trifluoromethyl)benzylic alcohol 
• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 87189-16-0 potassium 2-bromo-2,2-difluoroacetate 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 1219454-89-3 2-((difluoromethyl)sulfonyl)pyridine 
• 1895-39-2 sodium chlorodifluoroacetate 
• 1600503-70-5 potassium 2-pyridinyl sulfonyl-difluoroacetate 
• 2925-16-8 1,1-difluoro-2-iodoethylene 
• 455-13-0 4-Iodobenzotrifluoride 

Downstream Products

• 2338-75-2 4-(Trifluoromethyl)phenylacetonitrile 
• 209845-76-1 (Z)-2-fluoro-3-(4-trifluoromethylphenyl)acrylic acid 
• 126976-31-6 methyl Z-2-fluoro-3-(4-trifluoromethylphenyl)prop-2-enoate 

Relevant articles and documents

Decarboxylative julia-kocienski gem-difluoro-olefination of 2-pyridinyl sulfonyldifluoroacetate

The decarboxylation of potassium 2-pyridinyl sulfonyldifluoroacetate and its subsequent reaction with aldehydes was found to be an efficient approach for the Julia-Kocienski reaction under mild conditions to give gem-difluoro olefins in moderate to excell

Fluoride-Triggered Synthesis of 1-Aryl-2,2-difluoroalkenes via Desilylative Defluorination of (1-Aryl)-2,2,2-trifluoroethyl-silanes

An efficient route for the synthesis of 1-aryl-2,2-difluoroalkenes via 1,2-desilylative defluorination is disclosed. Only a catalytic amount of fluoride source is required to initiate the desilylation and afford gem-difluoroalkenes in very good to quantitative yields, using mild reaction conditions in dimethyl carbonate as a green solvent. This reaction uses (1-aryl)-2,2,2-trifluoroethyl-silanes, which are easily prepared via the insertion reaction of trifluoroethyl diazo alkanes into the Si-H bond of tertiary organosilanes. (1-Aryl)-perfluoroalkyl-silanes cleanly afford the corresponding (Z)-1-benzylideneperfluoroalkanes, which upon hydrodefluorination furnish the (E)-β(perfluoroalkyl)styrene derivatives with excellent yield and complete stereoselectivity. A one-pot system involving sequential insertion and desilylative-defluorination is also suitable for this transformation. This method demonstrates the usefulness of organosilanes toward the preparation of fluorinated alkenes as synthetically useful targets.

-Annulation of gem-Difluoroalkenes and Pyridinium Ylides: Access to Functionalized 2-Fluoroindolizines

A [3 + 2]-annulation of gem-difluoroalkenes and pyridinium ylides was developed employing ambient air as the sole oxidant in an open-vessel manner, affording a series of multifunctionalized 2-fluoroindolizines in moderate to good yields. In this reaction, gem-difluoroalkene acts as a C2 synthon and entirely avoids the competitive addition-elimination process, which provides facile access to 2-fluoroindolizines.