771-76-6

Basic information

• Product Name: 2-CHLORO-4,5-DIFLUORONITROBENZENE
• Synonyms: 2-CHLORO-4,5-DIFLUORONITROBENZENE;1-Chloro-4,5-difluoro-2-nitrobenzene
• CAS NO: 771-76-6
• Molecular Formula: C₆H₂ClF₂NO₂
• Molecular Weight: 193.54
• Mol File: 771-76-6.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 118 °C(Press: 31 Torr)
• Appearance: /
• Density: 1.591±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-CHLORO-4,5-DIFLUORONITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CHLORO-4,5-DIFLUORONITROBENZENE(771-76-6)
• EPA Substance Registry System: 2-CHLORO-4,5-DIFLUORONITROBENZENE(771-76-6)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 771-76-6(Hazardous Substances Data)

Usage

General Description

2-Chloro-4,5-difluoronitrobenzene is a chemical compound with the molecular formula C6H3ClF2NO2. It is a pale yellow solid that is commonly used as an intermediate in the production of pharmaceuticals and agrochemicals. 2-CHLORO-4,5-DIFLUORONITROBENZENE is a highly reactive and versatile building block, often undergoing substitution, reduction, or coupling reactions to create a variety of other organic compounds. Due to its potential toxicity and environmental impact, proper handling and disposal procedures must be followed when working with 2-Chloro-4,5-difluoronitrobenzene.

Upstream product

• 696-02-6 4-chloro-1,2-difluorobenzene 

Downstream Products

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• 847872-10-0 4-amino-5-chloro-2-fluoro-phenol 
• 1093221-99-8 di(tert-butyl) (5-chloro-2-fluoro-4-nitrophenyl)malonate 
• 212694-66-1 2-chloro-5-fluoro4-piperazinonitrobenzene 
• 212914-52-8 2-chloro4-diethylamino-5-fluoronitrobenzene 
• 2267-98-3 6-chloro-3,4-difluorophenol 
• 949559-51-7 1-(4-methoxybenzyl)-4-(5-chloro-2-fluoro-4-nitrophenoxy)-3-iodo-1H-pyrazolo[3,4-b]pyridine 
• 2613-32-3 2-chloro-4,5-difluoroaniline 

Relevant articles and documents

SUBSTITUTED PYRAZOLONE COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted pyrazolone compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

SUBSTITUTED QUINOLINE COMPOUNDS AND METHODS OF USE

The present invention provides novel substituted quinoline compounds, pharmaceutical acceptable salts and formulations thereof useful in modulating the protein tyrosine kinase activity, and in modulating cellular activities such as proliferation, differentiation, apoptosis, migration and invasion. The invention also provides pharmaceutically acceptable compositions comprising such compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

Identification of 4-[1-[3-chloro-4-[N'-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist

Optimization of benzoic acid derivatives by introducing substituents into the diphenyl urea moiety led to the identification of compound 20l as a potent VLA-4 antagonist. Compound 20l inhibited eosinophil infiltration into bronchial alveolar lavage fluid