696-02-6

Basic information

• Product Name: 1-Chloro-3,4-difluorobenzene
• Synonyms: Benzene,4-chloro-1,2-difluoro-;1-Chloro-3,4-difluorobenzene, 97% [4-Chloro-1,2-difluorobenzene];1-Chloro-3,4-difluorobenzene~3,4-Difluorochlorobenzene;4-BROMO-2-BENZONITRILE-4-CHLORO-1,2-DIFLUOROBENZENE;1-Chloro-3,4-difluorobenzene 98%;1-Chloro-3,4-difluorobenzene98%;1-Chloro-3,4-difluorobenzene,99%;4-Bromo-2-Benzonitri
• CAS NO: 696-02-6
• Molecular Formula: C₆H₃ClF₂
• Molecular Weight: 148.54
• EINECS: -0
• Product Categories: Aromatic Hydrocarbons (substituted) & Derivatives;Heterocyclic Compounds;Chlorine Compounds;Fluorine Compounds;Aryl;C6;Halogenated Hydrocarbons;Fluorine series;Halogenated Heterocycles ,Thiophenes
• Mol File: 696-02-6.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 126 °C(lit.)
• Flash Point: 96 °F
• Appearance: Clear colourless to light yellow liquid
• Density: 1.33 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.475(lit.)
• Storage Temp.: Sealed in dry,Room Temperature
• BRN: 2081081
• CAS DataBase Reference: 1-Chloro-3,4-difluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Chloro-3,4-difluorobenzene(696-02-6)
• EPA Substance Registry System: 1-Chloro-3,4-difluorobenzene(696-02-6)

Safety Data

• Hazard Codes: Xn,F,Xi,N
• Statements: 10-22-36/37/38
• Safety Statements: 16-26-36-37/39
• RIDADR: UN 1993 3/PG 3
• WGK Germany: 3
• HazardClass: 3
• PackingGroup: III
• Hazardous Substances Data: 696-02-6(Hazardous Substances Data)

Usage

Description

1-Chloro-3,4-difluorobenzene is an organic compound with the chemical formula C6H2ClF2. It is a derivative of benzene, featuring one chlorine atom and two fluorine atoms attached to the benzene ring. 1-Chloro-3,4-difluorobenzene is known for its unique chemical properties and potential applications in various industries.

Uses

Used in Chemical Synthesis:
1-Chloro-3,4-difluorobenzene is used as a key intermediate in the synthesis of various organic compounds and pharmaceuticals. Its presence of chlorine and fluorine atoms allows for further functionalization and the formation of a wide range of derivatives.
Used in Pharmaceutical Industry:
1-Chloro-3,4-difluorobenzene is used as a building block for the development of new drugs and pharmaceutical agents. Its unique structure and reactivity make it a valuable component in the design and synthesis of novel therapeutic agents.
Used in Agrochemical Industry:
1-Chloro-3,4-difluorobenzene is used as a precursor in the production of agrochemicals, such as insecticides, herbicides, and fungicides. Its chemical properties enable the development of effective and targeted pest control solutions.
Used in Dye and Pigment Industry:
1-Chloro-3,4-difluorobenzene is used as a starting material for the synthesis of dyes and pigments. Its ability to form various derivatives allows for the creation of a diverse range of colorants for use in various applications, such as textiles, plastics, and printing inks.
Used in Preparation of 1-Chloro-4,5-difluoro-2-nitrobenzene:
1-Chloro-3,4-difluorobenzene is used as a reactant in the preparation of 1-chloro-4,5-difluoro-2-nitrobenzene, which is an important compound for further chemical transformations and applications in various industries.

InChI:InChI=1/C6H3ClF2/c7-4-1-2-5(8)6(9)3-4/h1-3H

Upstream product

• 106-46-7 para-dichlorobenzene 
• 367-11-3 ortho-difluorobenzene 
• 3863-11-4 3,4-difluoroaniline 
• 356-77-4 1,1,2,2-tetrafluoro-3-vinylcyclobutane 
• 2646-83-5 3,3,4,4-tetrafluorocyclohexene 
• 108-90-7 chlorobenzene 
• 2106-05-0 5-chloro-2-fluoroaniline 
• 345-18-6 2-fluoro-5-chloronitrobenzene 
• 360-47-4 3-(1-chloro-vinyl)-1,1,2,2-tetrafluoro-cyclobutane 
• 356-96-7 1-chloro-2,2,3,3-tetrafluoro-1-vinyl-cyclobutane 
• 89-61-2 2,5-dichloronitrobenzene 

Downstream Products

• 771-76-6 2-chloro-4,5-difluoronitrobenzene 
• 121872-94-4 2'-chloro-4',5'-difluoroacetophenone 
• 133117-00-7 2-chloro-4,5-difluoro-α-chloroacetophenone 
• 367-11-3 ortho-difluorobenzene 
• 1214273-28-5 C₁₂H₁₅BF₂O₂ 
• 38964-22-6 2,8-dichlorodibenzodioxin 
• 1552281-02-3 4-(5-chloro-4-(1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamido)-2-fluorophenoxy)picolinamide 
• 847872-10-0 4-amino-5-chloro-2-fluoro-phenol 
• 1437034-25-7 (R)-2-(4-(5-chloro-2-fluorophenoxy)phenyl)-6-(1,2-dihydroxyethyl)pyrimidine-4-carboxamide 
• 1437034-77-9 C₁₉H₁₃ClFN₃O₂ 
• 1437034-76-8 C₁₉H₁₂ClFN₂O₃ 
• 1437034-72-4 2-(4-(5-chloro-2-fluorophenoxy)phenyl)-4,4,5,5-tetramethyl-1,3,3-dioxaborolane 
• 1374400-73-3 methyl 3-(3,4-difluorophenyl)indolizine-2-carboxylate 
• 59447-06-2 1-bromo-2-chloro-4,5-difluorobenzene 

Relevant articles and documents

Three-step regioselective synthesis of 2,3-difluorohalobenzenes using tetrafluoroethylene and buta-1,3-diene as starting building blocks

The gas-phase copyrolysis of tetrafluoroethylene and buta-1,3-diene in a flow tube reactor at 490–510 °C gives 3,3,4,4-tetrafluorocyclohex-1-ene, which is selectively converted to 1-bromo- or 1-chloro-2,3-difluorobenzene via intermediate steps of halogenation and dehydrohalogenation.

Method for producing tetrakis ( fluoroaryl) borate-magnesium compound

Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.

Process for producing chlorofluorobenzenes

A process for producing chlorofluorobenzenes, which comprises reacting fluorine-containing nitrobenzenes of the following formula (1) with chlorine gas to obtain chlorofluorobenzenes of the following formula (2): STR1 wherein n and m are integers satisfying 1≤n≤3, 0≤m≤2 and 1≤n+m≤3.