81136-08-5

Basic information

• Product Name: (R)-α-methylhydrocynnamic acid chloride
• CAS NO: 81136-08-5
• Molecular Weight: 182.65
• Mol File: 81136-08-5.mol
• Article Data: 25

Chemical Properties

• CAS DataBase Reference: (R)-α-methylhydrocynnamic acid chloride(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-α-methylhydrocynnamic acid chloride(81136-08-5)
• EPA Substance Registry System: (R)-α-methylhydrocynnamic acid chloride(81136-08-5)

Safety Data

• Hazardous Substances Data: 81136-08-5(Hazardous Substances Data)

Upstream product

• 1009-67-2 2-methyl-3-phenylpropanoic acid 
• 29393-16-6 methyl 2-methyl-3-phenylpropionate 
• 14366-89-3 methyl 3-hydroxy-2-methyl-3-phenylpropanoate 
• 100-52-7 benzaldehyde 
• 1199-77-5 α-methylcinnamic acid 
• 501-52-0 3-Phenylpropionic acid 
• 100-44-7 benzyl chloride 
• 34666-01-8 ethyl 2-methyl-3-phenylpropionate 
• 1009-67-2 2-methyl-3-phenylpropionic acid 
• 14367-67-0 2-methyl-3-phenylpropionic acid 

Downstream Products

• 92579-32-3 2-methyl-3-phenyl-propionic acid-[2]pyridylamide 
• 195832-99-6 (2S)-2-methyl-1,3-diphenyl-propan-1-one 
• 155129-95-6 2-benzyl-N-methyl-N-phenylpropanamide 
• 16583-69-0 α-Benzyl-N-ethylpropionamide 
• 130296-14-9 N-(6-Amino-2,4-dioxo-1,3-dipropyl-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2-methyl-3-phenyl-propionamide 
• 155675-22-2 (S)-2-Methyl-3-phenyl-propionic acid (R)-3-iodo-2-methyl-propyl ester 
• 65870-05-5 2-Methyl-3-phenyl-propionic acid 2-ethyl-3H-inden-1-yl ester 
• 65869-97-8 3-(2-methyl-3-phenyl-propionyloxy)-2-methyl-indene 
• 65869-99-0 2-Methyl-2-(2-methyl-3-phenyl-propionyl)-indan-1-one 
• 484689-80-7 (RS,SS)-2-Methyl-3-phenyl-1-<2-(1-methoxy-1-methylethyl)pyrrolidin-1-yl>propan-1-on 
• 634600-98-9 2-methyl-3-phenylpropionic acid 2-trimethylsilanylmethylallyl ester 
• 886040-88-6 5-chloro-2-(2-methyl-3-phenyl-propionylamino)-benzoic acid methyl ester 
• 21869-55-6 3-methyl-4-phenylbutan-2-one 
• 124805-03-4 ((E)-1-Chloro-2-methyl-3-phenyl-propenyl)-dimethyl-amine 

Relevant articles and documents

Catalytic enantioselective desymmetrization of cyclobutane-1,3diones by carbonyl-amine condensation

A chiral phosphoric acid-catalyzed enantioselective condensation of 2,2-disubstituted cyclobutane-1,3-diones with a primary amine is described. This reaction offered a mild and efficient protocol for constructing quaternary carbon-containing cyclobutanes

Selective Inhibitors of a Human Prolyl Hydroxylase (OGFOD1) Involved in Ribosomal Decoding

Human prolyl hydroxylases are involved in the modification of transcription factors, procollagen, and ribosomal proteins, and are current medicinal chemistry targets. To date, there are few reports on inhibitors selective for the different types of prolyl hydroxylases. We report a structurally informed template-based strategy for the development of inhibitors selective for the human ribosomal prolyl hydroxylase OGFOD1. These inhibitors did not target the other human oxygenases tested, including the structurally similar hypoxia-inducible transcription factor prolyl hydroxylase, PHD2.

Palladium-Catalyzed Carbon Isotope Exchange on Aliphatic and Benzoic Acid Chlorides

An operationally simple protocol for a palladium-catalyzed 13CO and 14CO exchange with activated aliphatic and benzoic carbonyls is presented. Several 13C and 14C building blocks, natural product derivatives, an