84030-13-7

Basic information

• Product Name: ()-1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methylisoquinoline-6,7-diol hydrobromide
• Synonyms: (1)-1-((3,4-Dihydroxyphenyl)methyl)-1,2,3,4-tetrahydro-2-methylisoquinoline-6,7-diol hydrobromide; 1-(3,4-dihydroxybenzyl)-2-methyl-1,2,3,4-tetrahydroisoquinoline-6,7-diol
• CAS NO: 84030-13-7
• Molecular Formula: BrH*C₁₇H₁₉NO₄
• Molecular Weight: 301.3371
• EINECS: 281-783-8
• Mol File: 84030-13-7.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 548°C at 760 mmHg
• Flash Point: 323°C
• Density: 1.373g/cm³
• Vapor Pressure: 1.28E-12mmHg at 25°C
• Refractive Index: 1.685
• CAS DataBase Reference: ()-1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methylisoquinoline-6,7-diol hydrobromide(CAS DataBase Reference)
• NIST Chemistry Reference: ()-1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methylisoquinoline-6,7-diol hydrobromide(84030-13-7)
• EPA Substance Registry System: ()-1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methylisoquinoline-6,7-diol hydrobromide(84030-13-7)

Safety Data

• Hazardous Substances Data: 84030-13-7(Hazardous Substances Data)

Usage

General Description

The chemical ()-1-[(3,4-dihydroxyphenyl)methyl]-1,2,3,4-tetrahydro-2-methylisoquinoline-6,7-diol hydrobromide is a synthetic compound that contains a tetrahydroisoquinoline core and a dihydroxyphenyl side chain. It is typically found in the form of a hydrobromide salt. This chemical has potential pharmacological activities and may be of interest in medicinal chemistry research. Its complex structure suggests the potential for multiple molecular interactions and biological activities, making it a candidate for further exploration in drug discovery and development.

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Relevant articles and documents

Potential cancer chemopreventive activity of simple isoquinolines, 1-benzylisoquinolines, and protoberberines

Seventeen simple isoquinolines, 15 1-benzylisoquinolines, and 19 protoberberines were tested for their inhibitory activities against Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol- 13-acetate (TPA) in Raji cells. Among the tested alkaloids, the inhibitory activity of all 1-benzylisoquinolines and 11 protoberberines was higher than that of β-carotene. The 1-benzylisoquinolines 19, 21, 22, 29, and 34 and protoberberines 41, 47-49, 51, 52, and 55 showed potent inhibitory effects on EBV-EA induction (96-100% inhibition at 1 × 103 mol ratio/TPA). These alkaloids were more active than the naturally occurring alkaloids, 23, 25, 33, 53, and 54. In addition, fifteen simple isoquinolines, eighteen 1-benzylisoquinolines and eight protoberberines were evaluated with respect to their ability to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radicals. Nine simple isoquinolines, ten 1-benzylisoquinolines, and four protoberberines were more potent than α-tocopherol, and four 1-benzylisoquinolines, 20 and 28-30, exhibited potent activities (SC50 4.5-5.8 μM). Their activities were higher than the naturally occurring alkaloids, 23, 25, and 33. Therefore, some of the isoquinoline alkaloids indicating the high activity on both assays may be potentially valuable cancer chemopreventive agents. Structure-activity relationships are discussed for both tests.