85259-19-4

Basic information

• Product Name: Methyl alpha-bromo-2-chlorophenylacetate
• Synonyms: a-Bromo-2-chlorobenzeneacetic Acid Methyl Ester;Methyl a-Bromo-2-chlorobenzeneacetat;Methyl a-Bromo-2-chlorophenylacetate;alpha-Bromo-2-chloro-phenylacetic acid methyl ester;Methyl alpha-bromo-2-chlorophenylacetate;Methyl α-Bromo-2-chlorobenzeneacetate;α-Bromo-2-chloro benzeneacetic Acid Methyl Ester;Methyl a-Bromo-2-chlorobenzeneacetate
• CAS NO: 85259-19-4
• Molecular Formula: C₉H₈BrClO₂
• Molecular Weight: 263.52
• EINECS: 617-693-6
• Product Categories: Chemical Activators;Activators
• Mol File: 85259-19-4.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 281 °C
• Flash Point: 124 °C
• Appearance: Light-Yellow Oil
• Density: 1.567
• Refractive Index: 1.5630 to 1.5670
• Storage Temp.: Refrigerator
• Solubility: Dichloromethane, Ether, Ethyl Acetate, Methanol
• CAS DataBase Reference: Methyl alpha-bromo-2-chlorophenylacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl alpha-bromo-2-chlorophenylacetate(85259-19-4)
• EPA Substance Registry System: Methyl alpha-bromo-2-chlorophenylacetate(85259-19-4)

Safety Data

• RIDADR: UN 3265 8/PG II
• HazardClass: 8
• PackingGroup: II
• Hazardous Substances Data: 85259-19-4(Hazardous Substances Data)

Usage

Description

Methyl alpha-bromo-2-chlorophenylacetate, with the chemical formula C9H8BrClO2 and CAS number 85259-19-4, is an organic compound that serves as a valuable intermediate in various chemical reactions and processes. Its unique structure, featuring a bromo and chloro substituent on a phenyl ring, endows it with specific reactivity and properties that make it suitable for a range of applications in organic synthesis.

Uses

Used in Organic Synthesis:
Methyl alpha-bromo-2-chlorophenylacetate is used as a synthetic intermediate for the preparation of various organic compounds. Its presence in reactions can facilitate the formation of new chemical entities, which can be further utilized in the development of pharmaceuticals, agrochemicals, or other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Methyl alpha-bromo-2-chlorophenylacetate is used as a key building block in the synthesis of certain drugs. Its unique functional groups can be manipulated to create molecules with specific biological activities, contributing to the discovery and development of new therapeutic agents.
Used in Agrochemical Development:
Methyl alpha-bromo-2-chlorophenylacetate also finds application in the agrochemical sector, where it is employed as a precursor in the synthesis of pesticides or other crop protection agents. Its reactivity and structural features can be leveraged to create compounds with targeted pest control properties.
Used in Specialty Chemicals Production:
In the production of specialty chemicals, Methyl alpha-bromo-2-chlorophenylacetate is utilized as a versatile intermediate. Its ability to participate in various types of chemical reactions allows for the creation of a wide array of specialty chemicals for use in industries such as plastics, coatings, and textiles.

InChI:InChI=1/C9H8BrClO2/c1-13-9(12)4-6-2-3-7(11)5-8(6)10/h2-3,5H,4H2,1H3

Upstream product

• 57486-68-7 methyl (2-chlorophenyl)acetate 
• 156276-21-0 rac-methyl 2-chloromandelate 
• 10421-85-9 2-chloromandelic acid 
• 101-41-7 benzeneacetic acid methyl ester 
• 29270-30-2 α-bromo-2-chlorophenyl acetic acid 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 67-56-1 methanol 
• 2444-36-2 2'-chloro-benzeneacetic acid 
• 51512-09-5 2-(2-chlorophenyl)acetyl chloride 
• 89-98-5 2-chloro-benzaldehyde 
• 138647-05-9 2-bromo-2-(2-chlorophenyl)acetyl chloride 

Downstream Products

• 767608-48-0 (2-Chloro-phenyl)-{4-[4-(4-cyano-phenyl)-thiazol-2-ylamino]-piperidin-1-yl}-acetic acid methyl ester 
• 181039-77-0 methyl (RS)-(5-allyloxy-2-cyanophenoxy)-(2-chlorophenyl)acetate 
• 181039-85-0 methyl (RS)-(2-chlorophenyl)-[2-cyano-5-(thien-3-ylmethoxy)phenoxy]acetate 
• 181040-08-4 methyl (RS)-[5-(1,3-benzodioxol-5-ylmethoxy)-2-cyanophenoxy]-(2-chlorophenyl)acetate 
• 141109-25-3 (S)-(+)-2-bromo-2-(2-chlorophenyl)acetic acid 
• 622835-93-2 (R)-2-bromo-2-(2-chlorophenyl)acetic acid methyl ester 
• 181039-78-1 methyl (RS)-(2-chlorophenyl)-[2-cyano-5-hydroxyphenoxy]acetate 
• 181039-80-5 methyl (RS)-(2-chlorophenyl)-[2-cyano-5-(pyridin-4-ylmethoxy)phenoxy]acetate 
• 181040-28-8 methyl (RS)-(2-chlorophenyl)-[2-cyano-5-(pyridazin-4-ylmethoxy)phenoxy]acetate 
• 181040-41-5 methyl (RS)-[5-(benzoxazol-6-ylmethoxy)-2-cyanophenoxy]-(2-chlorophenyl)acetate 
• 137314-33-1 methyl 2-(4-methylphenoxy)-2-(2'-chlorophenyl)acetate 
• 90055-48-4 clopidogrel 
• 135046-48-9 clopidogrel bisulfate 
• 1373492-32-0 (2-chlorophenyl)-(3-oxo-3,6-dihydro-2H-pyridin-1-yl)acetic acid methyl ester 

Relevant articles and documents

Method for preparing clopidogrel intermediate alpha-bromo (2-chloro) methyl phenylacetate by recycling aqueous solution method

The invention provides a method for preparing clopidogrel intermediate alpha-bromo (2-chloro) methyl phenylacetate by recycling an aqueous solution method. According to the method, o-chlorophenylacetic acid is adopted as a main raw material, an organic solvent and water in an appropriate proportion are optimized to serve as a bromination mixed solvent, a two-phase reaction mode is adopted in the reaction process, a bromine-containing wastewater solution can be reused without complex treatment, a target product is prepared through bromination and esterification reactions, and the yield reaches78% or above; the method provided by the invention is based on a technical scheme of recycling an aqueous solution containing a bromination reagent. In the process production process, the input amountof a new bromination reagent is reduced to a great extent, the bromine atom utilization rate of the bromination reagent is increased, the problems of wastewater treatment and discharge are reduced, the pressure of environmental pollution is reduced, meanwhile, the reaction conditions are relatively mild, treatment is simple, and industrial production is facilitated.

HYDROPHILIC COMPOUNDS FOR OPTICALLY ACTIVE DEVICES

The present invention relates to novel compounds, particularly to compounds comprising a photoactive unit, said novel compounds being particularly suitable for compositions and ophthalmic devices as well as to compositions and ophthalmic devices comprising such compounds.

Synthesis and Antibacterial Screening of 1,3,4-Thiadiazoles, 1,2,4-Triazoles, and 1,3,4-Oxadiazoles Containing Piperazine Nucleus

A series of novel 1,3,4-thiadiazoles, 1,2,4-triazoles, and 1,3,4-oxadiazoles were synthesized by cyclization of substituted 1-(2-(2-chlorophenyl)-2-(4-(2,3-dichlorophenyl)piperazin-1-yl)acetyl)thiosemicarbazide. The structures of all newly synthesized compounds were elucidated on the basis of spectral studies. Some of them were screened for their antibacterial activity. The compounds 6b, 6c, 8e, 9a, and 9b have shown moderate activity towards Bacillus Subtilis and Escherichia Coli.