86489-64-7

Basic information

• Product Name: N-benzyl-3,4-dimethoxybenzamide
• Synonyms: N-benzyl-3,4-dimethoxybenzamide
• CAS NO: 86489-64-7
• Molecular Weight: 271.316
• Mol File: 86489-64-7.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: N-benzyl-3,4-dimethoxybenzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzyl-3,4-dimethoxybenzamide(86489-64-7)
• EPA Substance Registry System: N-benzyl-3,4-dimethoxybenzamide(86489-64-7)

Safety Data

• Hazardous Substances Data: 86489-64-7(Hazardous Substances Data)

Upstream product

• 93-07-2 Veratric acid 
• 100-46-9 benzylamine 
• 83735-51-7 3,4-dimethoxybenzoic acid 2,5-dioxo-1-pyrrolidinyl ester 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 3535-37-3 3,4-dimethoxybenzoic acid chloride 
• 1521-41-1 veratramide 
• 100-51-6 benzyl alcohol 

Downstream Products

• 1144526-59-9 5-benzyl-1,2-dimethoxydibenzo[cd,f]indol-4(5H)-one 
• 1613320-07-2 2-(benzylcarbamoyl)-4,5-dimethoxyphenyl 4-chlorobenzoate 
• 81819-71-8 N-benzyl-3,4-dihydroxy-benzamide 

Relevant articles and documents

N -Heterocyclic carbene (NHC) catalyzed amidation of aldehydes with amines via the tandem N -hydroxysuccinimide ester formation

A facile method for the amidation of aldehydes by a cascade approach was developed. This methodology, reported for the first time, uses a N-heterocyclic carbene (NHC) as the catalyst, and N-hydroxysuccinimide (NHS) mediated synthesis of amides utilising TBHP as the oxidant. Various substituted aldehydes reacted smoothly with NHS giving the corresponding active esters in moderate to good yields, which facilely converted into amides in one pot. In addition, the drug moclobemide was synthesized to represent the practical utility of the developed methodology. This journal is

Synthesis of amides from acid chlorides and amines in the bio-based solvent Cyrene

Cyrene as a bio-alternative dipolar aprotic solvent: a waste minimizing and molar efficient protocol for the synthesis of amides from acid chlorides and primary amines in the bio-available solvent Cyrene is disclosed. This protocol removed the use of toxic solvents, such as dimethylformamide and dichloromethane. A simple aqueous work-up procedure for the removal of the high boiling solvent Cyrene resulted in up to a 55-fold increase in molar efficiency (Mol E.%) versus standard operating procedures. In order to rapidly compare the molar efficiency of this process against other methodologies an Excel based Mol. E% calculator was developed that automates many of the calculations. An investigation into the hydration of Cyrene found that it readily hydrates to form a geminal diol in the presence of water and that this process is exothermic.

Hansch analysis of veratric acid derivatives as antimicrobial agents

The synthesis, characterization and antimicrobial evaluation of a new series of veratric acid derivatives are presented. Preliminary in vitro antimicrobial activity of the title compounds was assessed against a panel of microorganisms including Gram-positive and Gram-negative bacteria and fungi. Some of the veratric acid derivatives exhibited significant in vitro antimicrobial activity. QSAR investigation applied to find a correlation between different physicochemical parameters of the veratric acid derivatives and their antimicrobial activity indicated the importance of topological parameters in describing the antimicrobial activity.