93-07-2Relevant articles and documents
ON THE KNOWLEDGE OF VIETNAMESE CITRONELLA OIL.
SCHMIDT,BERNHARDT,MUEHLSTAEDT
, p. 544 - 548 (1963)
-
-
Bruhn,Agurell
, p. 574,575 (1974)
-
Enzymatic oxidation of manganese ions catalysed by laccase
Gorbacheva, Marina,Morozova, Olga,Shumakovich, Galina,Streltsov, Alexander,Shleev, Sergey,Yaropolov, Alexander
, p. 1 - 5 (2009)
The principal possibility of enzymatic oxidation of manganese ions by fungal Trametes hirsuta laccase in the presence of oxalate and tartrate ions, whereas not for plant Rhus vernicifera laccase, was demonstrated. Detailed kinetic studies of the oxidation of different enzyme substrates along with oxygen reduction by the enzymes show that in air-saturated solutions the rate of oxygen reduction by the T2/T3 cluster of laccases is fast enough not to be a readily noticeable contribution to the overall turnover rate. Indeed, the limiting step of the oxidation of high-redox potential compounds, such as chelated manganese ions, is the electron transfer from the electron donor to the T1 site of the fungal laccase.
-
Shakirov,Yunusov
, (1971)
-
-
Bruhn,Sanchez-Mejorada
, p. 622 (1977)
-
The structure of akiferinin
Kadyrov,Saidkhodzhaev
, p. 112 - 113 (1978)
-
Kinetics and process parameter studies in catalytic air oxidation of veratraldehyde to veratric acid
Mukhopadhyay, Sudip
, p. 365 - 369 (1999)
Kinetics and different process parameters for the air oxidation of veratraldehyde to veratric acid were studied. At a temperature of 130 °C, air pressure of 1 MPa, cobalt acetate loading of 0.03 mol/L, and an initial concentration of 30% w/v of veratraldehyde, the reaction was found to be first order with respect to veratraldehyde. In 3 h at an aldehyde conversion level of 100%, as high as 99% selectivity was achieved.
Polyhydroxybenzoic acid derivatives as potential new antimalarial agents
Degotte, Gilles,Francotte, Pierre,Pirotte, Bernard,Frédérich, Michel
, (2021/08/07)
With more than 200 million cases and 400,000 related deaths, malaria remains one of the deadliest infectious diseases of 2021. Unfortunately, despite the availability of efficient treatments, we have observed an increase in people infected with malaria since 2015 (from 211 million in 2015 to 229 million in 2019). This trend could partially be due to the development of resistance to all the current drugs. Therefore, there is an urgent need for new alternatives. We have, thus, selected common natural scaffolds, polyhydroxybenzoic acids, and synthesized a library of derivatives to better understand the structure–activity relationships explaining their antiplasmodial effect. Only gallic acid derivatives showed a noticeable potential for further developments. Indeed, they showed a selective inhibitory effect on Plasmodium (IC50 ~20 μM, SI > 5) often associated with interesting water solubility. Moreover, this has confirmed the critical importance of free phenolic functions (pyrogallol moiety) for the antimalarial effect. Methyl 4-benzoxy-3,5-dihydroxybenzoate (39) has, for the first time, been recognized as a potential lead for future research because of its marked inhibitory activity against Plasmodium falciparum and its significant hydrosolubility (3.72 mM).
Selectively Upgrading Lignin Derivatives to Carboxylates through Electrochemical Oxidative C(OH)?C Bond Cleavage by a Mn-Doped Cobalt Oxyhydroxide Catalyst
Zhou, Hua,Li, Zhenhua,Xu, Si-Min,Lu, Lilin,Xu, Ming,Ji, Kaiyue,Ge, Ruixiang,Yan, Yifan,Ma, Lina,Kong, Xianggui,Zheng, Lirong,Duan, Haohong
supporting information, p. 8976 - 8982 (2021/03/16)
Oxidative cleavage of C(OH)?C bonds to afford carboxylates is of significant importance for the petrochemical industry and biomass valorization. Here we report an efficient electrochemical strategy for the selective upgrading of lignin derivatives to carboxylates by a manganese-doped cobalt oxyhydroxide (MnCoOOH) catalyst. A wide range of lignin-derived substrates with C(OH)-C or C(O)-C units undergo efficient cleavage to corresponding carboxylates in excellent yields (80–99 %) and operational stability (200 h). Detailed investigations reveal a tandem oxidation mechanism that base from the electrolyte converts secondary alcohols and their derived ketones to reactive nucleophiles, which are oxidized by electrophilic oxygen species on MnCoOOH from water. As proof of concept, this approach was applied to upgrade lignin derivatives with C(OH)-C or C(O)-C motifs, achieving convergent transformation of lignin-derived mixtures to benzoate and KA oil to adipate with 91.5 % and 64.2 % yields, respectively.