866943-87-5

Basic information

• Product Name: (S)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-p-tolylsulfanylmethylpentan-2-ol
• Synonyms: (S)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-p-tolylsulfanylmethylpentan-2-ol
• CAS NO: 866943-87-5
• Molecular Weight: 400.481
• Mol File: 866943-87-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (S)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-p-tolylsulfanylmethylpentan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-p-tolylsulfanylmethylpentan-2-ol(866943-87-5)
• EPA Substance Registry System: (S)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-p-tolylsulfanylmethylpentan-2-ol(866943-87-5)

Safety Data

• Hazardous Substances Data: 866943-87-5(Hazardous Substances Data)

Upstream product

• 400-31-7 1,1,1-trifluoro-4-methyl-pent-3-en-2-one 
• 1519-39-7 (R)-methyl p-tolyl sulfoxide 
• 866943-85-3 (S)-1,1,1-trifluoro-4-(5-fluoro-2-methylphenyl)-4-methyl-2-((R)-toluene-4-sulfinylmethyl)pentan-2-ol 

Downstream Products

• 1198785-20-4 (S)-6-(5-fluoro-2-methylphenyl)-6-methyl-4-(trifluoromethyl)hept-1-yn-4-ol 

Relevant articles and documents

GLUCOCORTICOID MIMETICS, METHODS OF MAKING THEM, PHARMACEUTICAL COMPOSITIONS, AND USES THEREOF

Compounds of Formula I wherein R1, R2, X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

Stereoselective synthesis of certain trifluoromethyl-substituted alcohols

A process for stereoselective synthesis of a compound of Formula (X) or Formula (X′) wherein R1, R2, and R3 are as defined herein, the process comprising: (a) reacting the starting material of formula A with a chiral sulfo