918-05-8

Basic information

• Product Name: N,N-DIMETHYL METHANESULFONAMIDE
• Synonyms: TIMTEC-BB SBB007962;N,N-DIMETHYL METHANESULFONAMIDE;N,N-DIMETHYLMETHANESULPHONAMIDE;N,N-Dimethyl methanesulfonamide, 98+%
• CAS NO: 918-05-8
• Molecular Formula: C₃H₉NO₂S
• Molecular Weight: 123.17
• EINECS: 213-039-5
• Mol File: 918-05-8.mol
• Article Data: 11

Chemical Properties

• Melting Point: 49 °C
• Boiling Point: 119-120°C 17mm
• Flash Point: 119-120°C/17mm
• Appearance: /
• Density: 1.158g/cm³
• Vapor Pressure: 1.84mmHg at 25°C
• Refractive Index: 1.45
• PKA: -3.35±0.70(Predicted)
• BRN: 1747409
• CAS DataBase Reference: N,N-DIMETHYL METHANESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYL METHANESULFONAMIDE(918-05-8)
• EPA Substance Registry System: N,N-DIMETHYL METHANESULFONAMIDE(918-05-8)

Safety Data

• Hazard Codes: T
• Safety Statements: S22:Do not inhale dust.; S24/25:Avoid contact with skin and eyes.
• HazardClass: TOXIC
• Hazardous Substances Data: 918-05-8(Hazardous Substances Data)

Usage

General Description

N,N-Dimethyl methanesulfonamide is an organic chemical compound with the formula C4H9NO2S. It is a colorless, odorless liquid that is soluble in water and commonly used as a solvent and reagent in various chemical and pharmaceutical processes. It is known for its strong solvating properties and can be used as a reaction medium in organic synthesis and as a carrier for drug delivery systems. Additionally, it has been studied for its potential applications in materials science and as an electrolyte additive in lithium-ion batteries. However, it is important to handle N,N-Dimethyl methanesulfonamide with caution as it is known to be a skin and eye irritant and may cause harm if ingested or inhaled.

InChI:InChI=1/C3H9NO2S/c1-4(2)7(3,5)6/h1-3H3

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 124-40-3 dimethyl amine 
• 51-80-9 bis-(dimethylamino)methane 
• 7143-01-3 Methanesulfonic anhydride 
• 79687-63-1 (1,1-Dioxo-3-phenyl-1λ⁶-thietan-3-yl)-dimethyl-amine; hydrochloride 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 506-59-2 N,N-dimethylammonium chloride 
• 1184-85-6 N-methylmethane sulphonamide 
• 1774-47-6 trimethylsulfoxonium iodide 
• 3144-09-0 methanesulfonamide 
• 74-88-4 methyl iodide 
• 99337-23-2 C₃H₉NO₂S 
• 71999-99-0 (1,1-Dioxo-3-phenyl-1λ⁶-thietan-3-yl)-dimethyl-amine 
• 676-85-7 methylsulphinyl chloride 

Downstream Products

• 2945-62-2 2-hydroxy-2,2-diphenyl-ethanesulfonic acid dimethylamide 
• 73281-91-1 N,N-dimethyl-2-oxo-2-phenylethane-1-sulfonamide 
• 109774-01-8 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2-(<(dimethylamino)sulfonyl>methylene)-2H-1,4-benzodiazepine 4-oxide 
• 109774-45-0 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-2-(<(dimethylamino)sulfonyl>methylene)-2H-1,4-benzodiazepine 4-oxide 
• 14894-42-9 Phenylmethanesulfonic acid N,N-dimethylamide 
• 691004-40-7 (N,N-dimethylsulfamoylmethyl)(3-methylphenyl)ketone 
• 141-97-9 ethyl acetoacetate 
• 112497-63-9 N,N-dimethyl-2-oxopropane-1-sulfonamide 
• 1402844-84-1 N-methyl-N-((2-phenyl-1H-imidazol-1-yl)methyl)methanesulfonamide 

Relevant articles and documents

Aryldiazonium bis(trifluoromethyl)imides

Aryldiazonium bis(trifluoromethyl)imides, [ArN2][N(CF 3)2], are the first examples of diazonium salts with this type of anion. Their syntheses and properties will be presented and compared to aryldiazonium bis(trifluoromethylsulfonyl)imides. [ArN2][N(CF 3)2] are less stable diazonium salts in comparison to [ArN2][N(SO2CF3)2] due to the higher nucleophilicity of the [N(CF3)2]- anion.

A useful Pd-catalyzed Negishi coupling approach to benzylic sulfonamide derivatives

(Chemical Equation Presented) A mild catalytic system to access diversely functionalized benzylic sulfonamides has been developed. Palladium-catalyzed α-arylation by Negishi cross-coupling of sulfonamide-stabilized anions and a wide range of aryl iodides, bromides, and triflates constitutes a practical strategy for the synthesis of various benzylic sulfonamides.