92-07-9Relevant articles and documents
Use of highly reactive, versatile and air-stable palladium-phosphinous acid complex [(t-Bu)2P(OH)]2PdCl2 (POPd) as a catalyst for the optimized Suzuki-Miyaura cross-coupling of less reactive heteroaryl chlorides and arylboronic acids
Khanapure, Subhash P.,Garvey, David S.
, p. 5283 - 5286 (2004)
Using highly reactive air-stable palladium-phosphinous acid complex [(t-Bu)2P(OH)]2PdCl2 (POPd) as a catalyst, synthesis of heteroaryl-aryl cross-coupled products via palladium-catalyzed Suzuki-Miyaura coupling of less reactive substituted 3-chloropyridines with arylboronic acids was achieved in high yields.
Selective Synthesis of Substituted Pyridines and Pyrimidines through Cascade Annulation of Isopropene Derivatives
Chen, Lu,He, Runfa,Huang, Yubing,Li, Jiaming,Li, Jian,Li, Yibiao,Liu, Jiasheng,Liu, Yang
supporting information, p. 1620 - 1625 (2022/03/14)
Diverse substituted pyridines and pyrimidines with high selectivity were obtained using a concise and efficient protocol developed herein. The reaction proceeds via metal-free cascade annulation of isopropene derivatives. Using isopropene derivatives as C3 synthons, NH4I as the “N” source, and formaldehyde or dimethyl sulfoxide as the carbon source, this reaction realizes the efficient formation of intermolecular C-N and C-C bonds.
Two C=C Bond Participation in Annulation to Pyridines Based on DMF as the Nonadjacent N and C Atom Donors
Su, Miao-Dong,Liu, Hai-Ping,Cao, Zhong-Zhong,Liu, Yufeng,Li, Hui,Nie, Zhi-Wen,Yang, Tong-Lin,Luo, Wei-Ping,Liu, Qiang,Guo, Can-Cheng
, p. 13446 - 13453 (2021/10/12)
Two C=C bond participation in annulation to pyridines using N,N-dimethylformamide (DMF) as the N1 and C4 synthons has been carried out. In this reaction, DMF contributed one N atom and one C atom to two disconnected positions of pyridine ring, with no need for an additional nitrogen source. Two C=C bonds in two molecules of substituted styrenes offered four carbon atoms in the presence of iodine and persulfate. With the optimized conditions in hand, both symmetric and unsymmetric diaryl-substituted pyridines were obtained in useful yields. On the basis of relevant literature and a series of control experimental results, a possible mechanism was proposed in this work, which may demonstrate how DMF provides both N1 and C4 sources.
Method for constructing 3,5-disubstituted pyridine by utilizing mixed styrene derivative and N,N-dimethylformamide
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Paragraph 0101-0107, (2020/08/27)
The invention discloses a method for constructing 3,5-disubstituted pyridine by utilizing mixed styrene derivative and N,N-dimethylformamide. The method comprises the following step: subjecting the mixed styrene derivative, N,N-dimethylformamide and peroxydisulfate to a cyclization reaction under the catalytic action of iodized salt so as to obtain symmetrical and asymmetrical mixed 3,5-disubstituted pyridine products at the same time. According to the method, 3,5-disubstituted pyridine is synthesized from the mixed styrene derivative and DMF through one-step oxidative cyclization under the catalysis of iodate; and the method has the advantages of low raw material and catalyst cost, mild reaction conditions, capability of realizing high-yield preparation of the symmetrical and asymmetrical3,5-disubstituted pyridine products at the same time and the like.
