94623-63-9

Basic information

• Product Name: N-(9H-fluoren-9-yl)-4-methylbenzenesulfonamide
• Synonyms: N-(9H-fluoren-9-yl)-4-methylbenzenesulfonamide
• CAS NO: 94623-63-9
• Molecular Weight: 335.426
• Mol File: 94623-63-9.mol
• Article Data: 16

Chemical Properties

• CAS DataBase Reference: N-(9H-fluoren-9-yl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(9H-fluoren-9-yl)-4-methylbenzenesulfonamide(94623-63-9)
• EPA Substance Registry System: N-(9H-fluoren-9-yl)-4-methylbenzenesulfonamide(94623-63-9)

Safety Data

• Hazardous Substances Data: 94623-63-9(Hazardous Substances Data)

Upstream product

• 1292302-62-5 N-(2-phenylbenzylidene)-4-methylbenzenesulfonamide 
• 1203-68-5 2-Phenylbenzaldehyde 
• 70-55-3 toluene-4-sulfonamide 
• 86-73-7 9H-fluorene 
• 7080-50-4 chloramine-T hydrate 
• 1689-64-1 9-Fluorenol 
• 98-80-6 phenylboronic acid 
• 6630-33-7 ortho-bromobenzaldehyde 
• 41085-71-6 bromamine T 
• 525-03-1 9-aminofluorene 
• 98-59-9 p-toluenesulfonyl chloride 
• 1940-57-4 9H-fluoren-9-yl bromide 
• 4083-64-1 Tosyl isocyanate 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 

Downstream Products

• 15718-00-0 1-(9H-fluoren-9-ylidene)-2-phenylhydrazine 
• 486-25-9 9-fluorenone 

Relevant articles and documents

PhI(OAc)2and iodine-mediated synthesis ofN-alkyl sulfonamides derived from polycyclic aromatic hydrocarbon scaffolds and determination of their antibacterial and cytotoxic activities

The development of new approaches toward chemo- and regioselective functionalization of polycyclic aromatic hydrocarbon (PAH) scaffolds will provide opportunities for the synthesis of novel biologically active small molecules that exploit the high degree of lipophilicity imparted by the PAH unit. Herein, we report a new synthetic method for C-X bond substitution that is speculated to operateviaa N-centered radical (NCR) mechanism according to experimental observations. A series of PAH sulfonamides have been synthesized and their biological activity has been evaluated against Gram-negative and Gram-positive bacterial strains (using a BacTiter-Glo assay) along with a series of mammalian cell lines (using CellTiter-Blue and CellTiter-Glo assays). The viability assays have resulted in the discovery of a number of bactericidal compounds that exhibit potency similar to other well-known antibacterials such as kanamycin and tetracycline, along with the discovery of a luciferase inhibitor. Additionally, the physicochemical and drug-likeness properties of the compounds were determined experimentally and usingin silicoapproaches and the results are presented and discussed within.

A Mononuclear Nonheme Iron(V)-Imido Complex

Mononuclear nonheme iron(V)-oxo complexes have been reported previously. Herein, we report the first example of a mononuclear nonheme iron(V)-imido complex bearing a tetraamido macrocyclic ligand (TAML), [(TAML)FeV(NTs)]? (1). The spectroscopic characterization of 1 revealed an S = 1/2 Fe(V) oxidation state, an Fe - N bond length of 1.65(4) ?, and an Fe - N vibration at 817 cm-1. The reactivity of 1 was demonstrated in C - H bond functionalization and nitrene transfer reactions.

Lewis acid-catalyzed tandem synthesis of 9-sulfonylamino- and 9-arylfluorenes

A Lewis acid-catalyzed three-step tandem synthesis of 9-arylfluorene was developed by simply heating a mixture of 2-formyl biphenyl, TsNCO and an arene. In the absence of arene, a two-step tandem synthesis of 9-sulfonylaminofluorene was achieved. These ad