946859-86-5

Basic information

• Product Name: tert-butyl N-[(1R,2R)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]carbamate
• Synonyms: tert-butyl N-[(1R,2R)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]carbamate
• CAS NO: 946859-86-5
• Molecular Weight: 345.417
• Mol File: 946859-86-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: tert-butyl N-[(1R,2R)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl N-[(1R,2R)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]carbamate(946859-86-5)
• EPA Substance Registry System: tert-butyl N-[(1R,2R)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]carbamate(946859-86-5)

Safety Data

• Hazardous Substances Data: 946859-86-5(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 40913-92-6 4-methylsulfonylbenzoyl chloride 
• 31925-29-8 (2S,3R)-2-amino-3-hydroxy-3-(4-methylsulfonylphenyl)propionic acid ethyl ester 

Downstream Products

• 946859-87-6 C₂₂H₂₉NO₈S₂ 
• 51458-28-7 (1R,2R)-2-amino-1-<4-(methylsulphonyl)phenyl>-1,3-propanediol 
• 76639-93-5 (1R,2S)-2-amino-3-fluoro-1-<4-(methylsulphonyl)phenyl>-1-propanol 
• 73231-34-2 Florfenicol 
• 108656-33-3 (1R,2S)-2-amino-3-fluoro-1-(4-methylsulphonylphenyl)-1-propanol hydrochloride 

Relevant articles and documents

Synthetic method of florfenicol intermediate

The invention relates to a synthetic method of a florfenicol intermediate. The synthetic method comprises following specific steps: compound II is dissolved in an organic solvent, under alkaline conditions, methyl sulfonyylation is carried out so as to obtain compound III; the compound III is subjected to ring closing reaction under alkaline conditions so as to obtain compound IV; and the compoundIV is subjected to fluorination ring opening reaction so as to obtain the florfenicol intermediate I. The synthetic method is novel in design, mild in conditions, and convenient in operation, and issuitable for industrialized production.

A (1R, 2R) - 1 - substituted phenyl - 2 - amino - 1, 3 - propanediol

The invention belongs to the technical field of pharmaceutical chemistry, and particularly relates to a synthesis method of (1R,2R)-1-substituted-phenyl-2-amino-1,3-propanediol. The preparation method comprises the following steps: rearranging 2-(N-substituted-oxyformacyl-substituted-benzoylamino)acetate to obtain 2-substituted-oxyformamido-3-substituted-phenyl-3-oxopropionate; and carrying out asymmetric transfer hydrogenation with dynamic resolution to obtain (2S,3S)-alpha-substituted-amino-beta-hydroxy ester, and carrying out configuration reversion and deprotection to obtain the (1R,2R)-1-substituted-phenyl-2-amino-1,3-propanediol. The method has the advantages of mild conditions and high optical purity, and is simple to operate and suitable for industrial production.

Fenicol compounds and methods synthesizing 2-trifluoroacetamido-3-substituted propiophenone compounds

Methods of preparing compounds of formula (I): wherein Y, Y1, and R2 are defined herein; methods of making D-(threo)-1-aryl-2-acylamido-1-propanol compounds, D-(threo)-1-aryl-2-acylamido-3-fluoro-1-propanol compounds, and D-(threo)-1