956631-60-0Relevant articles and documents
Development of safe and scalable continuous-flow methods for palladium-catalyzed aerobic oxidation reactions
Ye, Xuan,Johnson, Martin D.,Diao, Tianning,Yates, Matthew H.,Stahl, Shannon S.
scheme or table, p. 1180 - 1186 (2010/10/20)
The synthetic scope and utility of Pd-catalyzed aerobic oxidation reactions has advanced significantly over the past decade, and these reactions have the potential to address important green-chemistry challenges in the pharmaceutical industry. This potential has not been realized, however, because safety concerns and process constraints hinder large-scale applications of this chemistry. These limitations are addressed by the development of a continuous-flow tube reactor, which has been demonstrated on several scales in the aerobic oxidation of alcohols. Use of a dilute oxygen gas source (8% O2 in N 2) ensures that the oxygen/organic mixture never enters the explosive regime, and efficient gas-liquid mixing in the reactor minimizes decomposition of the homogeneous catalyst into inactive Pd metal. These results provide the basis for large-scale implementation of palladium-catalyzed (and other) aerobic oxidation reactions for pharmaceutical synthesis. The Royal Society of Chemistry 2010.
Dibenzyl Amine Compounds and Derivatives
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Page/Page column 34, (2010/11/28)
Dibenzyl amine compounds and derivatives, pharmaceutical compositions containing such compounds and the use of such compounds to elevate certain plasma lipid levels, including high density lipoprotein-cholesterol and to lower certain other plasma lipid le
