99357-68-3

Basic information

• Product Name: 2-ethyl-4-thiocyanatophenol
• Synonyms: 2-ethyl-4-thiocyanatophenol
• CAS NO: 99357-68-3
• Molecular Weight: 179.243
• Mol File: 99357-68-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-ethyl-4-thiocyanatophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-ethyl-4-thiocyanatophenol(99357-68-3)
• EPA Substance Registry System: 2-ethyl-4-thiocyanatophenol(99357-68-3)

Safety Data

• Hazardous Substances Data: 99357-68-3(Hazardous Substances Data)

Upstream product

• 90-00-6 o-Hydroxyethylbenzene 
• 540-72-7 sodium thiocyanide 

Downstream Products

• 1268500-80-6 2-ethyl-4-{[4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl]methylthio}phenol 
• 1268500-88-4 ethyl 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}acetate 
• 1268500-90-8 ethyl 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoate 
• 1268500-92-0 ethyl 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoate 
• 1268500-56-6 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}acetic acid 
• 1268500-58-8 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}propanoic acid 
• 1268500-60-2 2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl)thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoic acid 
• 1207268-91-4 ethyl 2-(2-ethyl-4-(1-(3-(4-methyl-5-oxo-1-(4-trifluoromethyl-phenyl)-4,5-dihydrogen-1H-1,2,4-triazolyl))-benzylthio)-phenoxy)-acetate 

Relevant articles and documents

COMPOUND WITH AGITATION EFFECT ON PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR , AND PREPARATION METHOD AND USE THEREOF

The present invention provides a novel compound of formula I, which has an agitation effect on the peroxisome proliferator-activated receptor subtype δ (PPARδ), to a pharmaceutical composition comprising the compound, to a process for preparation of the compound and to use of the compound in the manufacture of a medicament for treating or preventing a disease which could be treated or prevented by activating PPARδ thereof, said disease is one or more from the group comprising metabolic syndrome, obesity, dyslipidemia, pathoglycemia, insulin resistance, senile dementia and tumors. The present invention also relates to a new intermediate used in the preparation of the novel compound and a process for preparation of the intermediate.

Synthesis, biological evaluation and molecular modeling of GW 501516 analogues

Eleven analogues of GW 501516 (1) were prepared and subjected to biological testing in a semi-high throughput human skeletal muscle cell assay. The assay testing indicated that all analogues elicited oxidation of oleic acid. Among the most potent agonists, 2e (2-{2-ethyl-4-[(4-methyl-2-(4-trifluoromethylphenyl) thiazol-5-yl)methylthio]phenoxy}-2-methylpropanoic acid), was also subjected to a luciferase-based transfection assay, which showed that this compound is a potent agonist against PPARδ and a moderate agonist against PPARα. Docking of compound 2e into PPARδ revealed that it occupied the agonist binding site and exhibited key hydrogen bonding interactions with His323, His449, and Tyr473. Eleven GW 501516 analogues were prepared and subjected to human skeletal muscle cells. The assay testing indicated that all analogues elicited oxidation of oleic acid. One of the analogues displayed dual agonist effects against both PPARα and PPARδ. Copyright