99493-93-3

Basic information

• Product Name: (S)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANOL
• Synonyms: S-PTF-PEL;(S)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANOL;(1S)-1-[4-(Trifluoromethyl)phenyl]ethan-1-ol;(-)-1-(p-Trifluoromethylphenyl)ethanol;(S)-1-[p-(Trifluoromethyl)phenyl]ethanol;(R)-alpha-Methyl-4-(trifluoromethyl)benzyl alcohol, 4-[(1S)-1-Hydroxyethyl]benzotrifluoride;Benzenemethanol, a-methyl-4-(trifluoromethyl)-, (aS)-
• CAS NO: 99493-93-3
• Molecular Formula: C₉H₉F₃O
• Molecular Weight: 190.16
• Mol File: 99493-93-3.mol
• Article Data: 251

Chemical Properties

• Boiling Point: 233℃
• Flash Point: 98℃
• Appearance: /
• Density: 1.234
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 13.98±0.20(Predicted)
• CAS DataBase Reference: (S)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANOL(99493-93-3)
• EPA Substance Registry System: (S)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANOL(99493-93-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 99493-93-3(Hazardous Substances Data)

Usage

General Description

(S)-1-[4-(trifluoromethyl)phenyl]ethanol is a chemical compound with the molecular formula C10H11FO. It is a white to light yellow solid that is used in various scientific research and chemical synthesis processes. It belongs to the class of organic compounds known as aromatic alcohols, which are compounds containing both an aromatic ring and a hydroxyl group. (S)-1-[4-(TRIFLUOROMETHYL)PHENYL]ETHANOL has a trifluoromethyl group attached to the phenyl ring, which gives it unique chemical properties. It is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other fine chemicals. Its precise applications and uses depend on the specific research or industrial process in which it is being employed.

Upstream product

• 455-19-6 4-Trifluoromethylbenzaldehyde 
• 544-97-8 dimethyl zinc(II) 
• 709-63-7 1-(4-trifluoromethylphenyl)ethanone 
• 99441-23-3 (S)-1-(p-(trifluoromethyl)phenyl)ethyl acid phthalate 
• 402-50-6 1-trifluoromethyl-4-vinyl-benzene 
• 1737-26-4 1-(4-trifluorophenyl)ethanol 
• 108-22-5 Isopropenyl acetate 
• 75-24-1 trimethylaluminum 
• 638-11-9 isopropyl butyrate 
• 274-07-7 benzo[1,3,2]dioxaborole 
• 137203-34-0 bis(trimethylaluminum)–1,4-diazabicyclo[2.2.2]octane adduct 
• 75-16-1 methylmagnesium bromide 
• 943-27-1 4'-t-butylacetophenone 
• 67-63-0 isopropyl alcohol 

Downstream Products

• 1737-26-4 (R)-1-[4-(trifluoromethyl)phenyl]ethan-1-ol 
• 854738-78-6 methyl ((1R,4S)-6-fluoro-4-hydroxy-8-(methylsulfonyl)-9-{(1S)-1-[4-(trifluoromethyl)phenyl]ethyl}-2,3,4,9-tetrahydro-1H-carbazol-1-yl) acetate 
• 1737-26-4 1-(4-trifluorophenyl)ethanol 
• 1195962-53-8 (R)-(1E)-1-(1-(4-(trifluoromethyl)phenyl)ethoxy)-2-methylpent-1-en-3-one 
• 544704-12-3 2-methyl-4-(4-methylpiperidin-4-yl)-1-[1-(4-trifluoromethylphenyl)ethyl]piperazine 
• 306293-41-4 Sch 350634 
• 306293-36-7 Sch 350581 
• 306296-99-1 4-Cyano-4-{(S)-3-methyl-4-[(S)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazin-1-yl}-piperidine-1-carboxylic acid tert-butyl ester 
• 306297-00-7 tert-butyl 4-methyl-4-((S)-3-methyl-4-((S)-1-(4-(trifluoromethyl)phenyl)ethyl)piperazin-1-yl)piperidine-1-carboxylate 
• 306296-87-7 1-[4(trifluoromethyl)-α(S)-methylbenzyl]-2(S)-methyl-4-(tert-butoxycarbonyl)piperazine 
• 306296-88-8 (S)-3-Methyl-4-[(R)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine-1-carboxylic acid tert-butyl ester 
• 306296-89-9 (S)-2-Methyl-1-[(S)-1-(4-trifluoromethyl-phenyl)-ethyl]-piperazine 

Relevant articles and documents

Nickel-Catalyzed Enantioselective Hydroboration of Vinylarenes

The enantioselective hydroboration of vinylarenes catalyzed by a chiral, nonracemic nickel catalyst is presented as a facile method for generating chiral benzylic boronate esters. Various vinylarenes react with bis(pinacolato)diboron (B2pin2) in the presence of MeOH as a hydride source to form chiral boronate esters in up to 92% yield with up to 94% ee. The use of anhydrous Me4NF to activate B2pin2 is crucial for ensuring fast transmetalation to achieve high enantioselectivities.

PQXdpap: Helical Poly(quinoxaline-2,3-diyl)s Bearing 4-(Dipropylamino)pyridin-3-yl Pendants as Chirality-Switchable Nucleophilic Catalysts for the Kinetic Resolution of Secondary Alcohols

Helically chiral poly(quinoxaline-2,3-diyl)s bearing 4-(dipropylamino)pyridin-3-yl pendants at the 5-position of the quinoxaline ring (PQXdpap) exhibited high catalytic activities and moderate to high selectivities (up to s = 87) in the acylative kinetic resolution of secondary alcohols. The solvent-dependent helical chirality switching of PQXdpap between pure toluene and a 1:1 mixture of toluene and 1,1,2-trichloroethane enabled the preparation of either compound of a pair of enantiomerically pure alcohols (>99% ee) from a single catalyst.

One-Pot Chemoenzymatic Conversion of Alkynes to Chiral Amines

A one-pot chemoenzymatic sequential cascade for the synthesis of chiral amines from alkynes was developed. In this integrated approach, just ppm amounts of gold catalysts enabled the conversion of alkynes to ketones (>99%) after which a transaminase was used to catalyze the production of biologically valuable chiral amines in a good yield (up to 99%) and enantiomeric excess (>99%). A preparative scale synthesis of (S)-methylbenzylamine and (S)-4-methoxy-methylbenzylamine from its alkyne form gave a yield of 59 and 92%, respectively, withee> 99%.