mandelonitrile synthesis
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Mandelonitrile synthesis
As the method of producing a mandelonitrile compound, it comprises reacting a benzaldehyde compound and hydrogen cyanide in the presence of an alkali metal salt in a water solvent. when the benzaldehyde compound has a substituent at an ortho position, the substituent hinders the reaction, and the yield of a mandelonitrile compound is not satisfactory in some cases.
The present invention has an object of providing a method for producing a mandelonitrile compound in good yield from a benzaldehyde compound having a prescribed substituent at an ortho position.
The present inventors have intensively studied and resultantly found that the above-described object can be attained by reacting a benzaldehyde compound having a prescribed substituent at an ortho position with hydrogen cyanide in an amount of 1.2 to 5 mol with respect to 1 mol of the benzaldehyde compound, in the presence of an organic base in an organic solvent, leading to completion of the present invention.
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JiangXi Keyuan Biopharma Co., LTD.
- Country: China (Mainland)
- Year Established: 2002
- Business License:
- Business type: Manufacturers
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