Silodosin
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1. The brief introduction of silodosin
Silodosin (CAS NO.160970-54-7) which can be provided by HANGZHOU HOLYPHARM BIOTECH CO.,LTD is an α1a-adrenoceptor antagonist. KMD 3213 is used in treatment of benign prostatic hypertophy. It belongs to Amines;Aromatics;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals. So urief is always used in pharmaceutical. Its Systematic name is 1-(3-Hydroxypropyl)-5-[(2R)-2-({2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl}amino)propyl]-7-indolinecarboxamide. And 160970-54-7 is the (R)-1-(3-Hydroxypropyl)-5-[2-[[2-[2-(2,2,2-trifluoroethoxy)phenoxy]ethyl]amino]propyl]indoline-7-carboxamide.
2. Other properties of silodosin
Silodosin structure:
(1)Molecular Formula: C25H32F3N3O4; (2)Average mass: 495.534485; (3)Monoisotopic mass: 495.234497; (4)ACD/LogP: 3.039; (5)ACD/LogD (pH 5.5): -0.07 ; (6)ACD/LogD (pH 7.4): 1.59 ; (7)ACD/BCF (pH 5.5): 1.00 ; (8)ACD/BCF (pH 7.4): 4.27 ; (9)ACD/KOC (pH 5.5): 1.00 ; (10)ACD/KOC (pH 7.4): 38.13 ; (11)#H bond acceptors: 7 ; (12)#H bond donors: 4 ; (13)#Freely Rotating Bonds: 14 ; (14)Polar Surface Area: 97.05 Å2 ; (15)Index of Refraction: 1.552 ; (16)Molar Refractivity: 126.826 cm3 ; (17)Molar Volume: 396.697 cm3 ; (18)Polarizability: 50.278 10-24cm3 ; (19)Surface Tension: 45.5519981384277 dyne/cm ; (20)Density: 1.249 g/cm3 ; (21)Flash Point: 317.537 °C ; (22)Enthalpy of Vaporization: 94.114 kJ/mol ; (23)Boiling Point: 601.436 °C at 760 mmHg ; (24)Vapour Pressure: 0 mmHg at 25°C
3. Silodosin Dosage
Silodosin (Rapaflo) is a medication for the symptomatic treatment of benign prostatic hyperplasia. 8 mg orally once a day with a meal when a adult are Benign Prostatic Hyperplasia. If need, Renal Dose Adjustments can adjust as follows:
CrCl 50 to 80 mL/min: No adjustment recommended
CrCl 30 to 50 mL/min: 4 mg once a day with a meal
CrCl less than 30 mL/min: Contraindicated
And the Liver Dose Adjustments can adjust as follows:
Mild or moderate hepatic impairment: No adjustment recommended
Severe hepatic impairment (Child-Pugh score greater than or equal to 10): Contraindicated
Verified Supplier
HANGZHOU HOLYPHARM BIOTECH CO.,LTD
- Country: China (Mainland)
- Year Established: 2009
- Business License:
- Business type: Other
- Integral:
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