1. The brief introduction of Aliskiren hemifumarate
Aliskiren hemifumarate whose CAS Register Number is 173334-58-2 is a hemifumarate salt form of Aliskiren. Aliskiren hemifumarate is a direct renin inhibitor with an IC50 of 0.72 nM against renin. Renin is the first enzyme in the renin-angiotensin-aldosterone system which plays a role in blood pressure control. Its Molecular Weight is 609.83. Its Formula is C₃₀H₅₃N₃O₆. It is also called "Rasilez".

2. Aliskiren hemifumarate MSDS
(1) Identification of substance:
Trade name: Aliskiren hemifumarate
Manufacturer/Supplier: HANGZHOU HOLYPHARM BIOTECH CO.,LTD
ManufacturerHazardous Ingredient: Aliskiren hemifumarate

(2) Hazards identification:
Hazard Description:
Toxic. Contains a pharmaceutically active ingredient.
Handling should only be performed by personnel trained and familiar with handling of potent active pharmaceutical ingredients.
Moderate to severe irritant to the skin and eyes.

(3) Handling and storage:
Information for safe handling: avoid inhalation and contact with skin, eyes and clothing; material may be an irritant.
Storage: store solid and solutions at -20°C

(4) Stability and reactivity:
Stability:stable if stored as directed; avoid strong oxidizing agents.
Thermal decomposition / conditions to be avoided:protect from light and heat.

(5) First aid measures:
After Inhalation: If inhaled, remove to fresh air; if breathing is difficult, give oxygen; if breathing stops, give artificial respiration.
After skin contact: flush with copious amounts of water; remove contaminated clothing and shoes; call a physician.
After eye contact: check for and remove contact lenses and flush with copious amounts of water; assure adequate flushing by separating the eyelids with fingers; call a physician.
After swallowing: if swallowed, wash out mouth with copious amounts of water; call a physician.

(6) Fire fighting measures:
Suitable extinguishing agents: water spray, carbon dioxide, dry chemical powder or foam.
Unusual fire hazard: emits toxic fumes such as carbon monoxide, etc.

(7) Accidental release measures:
Person-related safety precautions: cordon off area of spill; wear self-contained breathing apparatus, protective clothing and heavy rubber gloves.
Measures for cleaning/collecting:absorb solutions with finely- powdered liquid-binding material (diatomite, universal binders); decontaminate surfaces and equipment by scrubbing with alcohol.

(8) Exposure controls and personal protection:
Personal protective equipment as follows:
Breathing equipment: NIOSH/MSHA-approved respirator.
Protection of hands: chemical-resistant rubber gloves.
Eye protection: chemical safety goggles.

Other information:
The above information is believed to be correct based on our present knowledge but does not purport to be complete. For research use only by trained personnel.