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tekturna
- Product Details
- Company Profile
1. Introduction of Tekturna
Tekturna (Aliskiren), with its cas register number 173334-57-1, can be called as (2S,4S,5S,7S)-5-Amino-N-(2-carbamoyl-2-methylpropyl)-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanamide. It is an orally active, synthetic nonpeptide renin inhibitor, used to be antihypertensive. The Classification Code of Aliskiren are as below: Antihypertensive; Renin Inhibitor; Treatment of essential hypertension [renin inhibitors].
2. Properties of Tekturna
Properties of Aliskiren (Tekturna) are as below: (1)ACD/LogP: 2.794; (2)# of Rule of 5 Violations: 2; (3)ACD/LogD (pH 5.5): -0.30; (4)ACD/LogD (pH 7.4): 0.12; (5)ACD/BCF (pH 5.5): 1.00; (6)ACD/BCF (pH 7.4): 1.00; (7)ACD/KOC (pH 5.5): 1.00; (8)ACD/KOC (pH 7.4): 1.69; (9)#H bond acceptors: 9; (10)#H bond donors: 6; (11)#Freely Rotating Bonds: 21; (12)Polar Surface Area: 146.13; (13)Index of Refraction: 1.514; (14)Molar Refractivity: 155.539 cm3; (15)Molar Volume: 516.977 cm3; (16)Polarizability: 61.66×10-24 cm3; (17)Surface Tension: 40.5839996337891 dyne/cm; (18)Density: 1.067 g/cm3; (19)Flash Point: 406.402 °C; (20)Enthalpy of Vaporization: 114.478 kJ/mol; (21)Boiling Point: 748.374 °C at 760 mmHg; (22)Vapour Pressure: 0 mmHg at 25°C.
You can still convert the following datas into molecular structure:
1). SMILES:O=C(N)C(C)(C)CNC(=O)[C@H](C(C)C)C[C@H](O)[C@@H](N)C[C@@H](C(C)C)Cc1cc(OCCCOC)c(OC)cc1
2). Std. InChI:InChI=1S/C30H53N3O6/c1-19(2)22(14-21-10-11-26(38-8)27(15-21)39-13-9-12-37-7)16-24(31)25(34)17-23(20(3)4)28(35)33-18-30(5,6)29(32)36/h10-11,15,19-20,22-25,34H,9,12-14,16-18,31H2,1-8H3,(H2,32,36)(H,33,35)/t22-,23-,24-,25-/m0/s1
3). Std. InChIKey:UXOWGYHJODZGMF-QORCZRPOSA-N
3. Side effects of Tekturna
When used as one renin Inhibitor, Tekturna has many adverse effects, such as Angioedema, Hyperkalemia, Hypotension and so on. But according to the researchers in Hangzhou Holypharm biotech Co.,Ltd., a professional supplier of active pharmaceutical ingredients and intermediates, it will be no much serious matters if you do after referring to your own doctor.
Verified Supplier
HANGZHOU HOLYPHARM BIOTECH CO.,LTD
- Country:
China (Mainland) - Year Established: 2009
- Business License:
- Business type: Other
- Integral:
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