- Imidazo[1,2-a]pyridine derivatives, methods of preparing the same and use thereof
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The present invention relates to an imidazo[1,2-a]pyridine derivative, and more specifically, to an imidazo[1,2-a]pyridine derivative having excellent gastric acid secretion inhibitory activity, a method of preparing the same, and a use thereof. The imidazo[1,2-a]pyridine derivative according to the present invention has gastric acid secretion inhibitory activity, and can be usefully applied for preventing or treating gastrointestinal inflammatory diseases or gastric-related diseases.(AA) Control group(BB) Example 6(CC) Example 7(DD) Embodiment 11COPYRIGHT KIPO 2017
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Paragraph 0138-0139
(2017/10/31)
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- Synthesis of Saturated Anacardic Acids, and Alkenyl and Alkynyl Analogues
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The C-alkylation of esters of 2-methoxy-6-methylbenzoic acid and of the 4-methyl isomers affords a route to homologous compounds including in the former case members of the natural anacardic acids from Anacardium occidentale and ω-alkynyl compounds suitable for synthesising other natural phenolic lipids or for structure/activity studies.
- Tyman, John H. P.,Visani, Naina
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p. 228 - 240
(2007/10/03)
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- Efficient total synthesis of AI-77-B, a gastroprotective substance from Bacillus pumilus AI-77
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First total synthesis of AI-77-B (1), a gastroprotective substance from Bacillus pumilus AI-77, was achieved in a stereoselective and convergent manner. In this synthesis, the dihydroisocoumarin part 2 was constructed in one step through 1,2-addition of the benzylic anion 17b to Boc-L-leucinal 7b. The hydroxy amino acid 4 was elaborated from (R)-glutamic acid in a highly stereoselective manner. Condensation of 2·HCl and 4, intramolecular Pinner reaction, followed by mild hydrolysis afforded AI-77-B (1).
- Hamada,Hara,Kawai,Kohno,Shioiri
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p. 8635 - 8652
(2007/10/02)
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- SYNTHETIC STUDIES ON NOGALAMYCIN CONGENERS ; SYNTHESES AND ANTITUMOR ACTIVITY OF VARIOUS NOGALAMYCIN CONGENERS
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Various structural types of nogalamycin congeners and their partial structures, which had been previously synthesized in the course of our synthetic studies on the total syntheses or were originally produced by employing the explored synthetic scheme, were subjected to in vitro cytotoxicity and in vivo antitumor activity assay against P388 murine leukemia.These studies obviously disclosed novel aspects of the structure-activity relationships of nogalamycin congeners.
- Matsuda, Fuyuhiko,Kawasaki, Motoji,Ohsaki, Masako,Yamada, Kaoru,Terashima, Shiro
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p. 5745 - 5760
(2007/10/02)
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- Synthesis of Gerberinol-I
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The synthesis of 4-hydroxy-5-methylcoumarin (II) is described.The compound (II) affords gerberinol-I (I) on treatment with formaldehyde.The synthetic sample of I is identical (m.m.p. and co-IR) with an authentic I.
- Chatterjea, J. N.,Singh, K. R. R. P.,Jha, I. S.,Prasad, Y.,Shaw, S. C.
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p. 796 - 798
(2007/10/02)
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- Asymmetric Synthesis of Mellein Methyl Ether: Use of ortho-Toluate Carbanions Generated by Chiral Bases
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An ortho-toluate carbanion generated from (2) by the chiral lithium amide base (6), (7), or (11) undergoes an enantioselective aldol-type reaction with acetaldehyde to give mellein methyl ether (3), in up to 53 percent enantiomeric excess.
- Regan, Andrew C.,Staunton, James
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p. 764 - 765
(2007/10/02)
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