Novel uncatalyzed hydrocyanation of ketones utlizing tetrachlorosilane- potassium cyanide reagent
A combination of tetrachlorosilane and potassium cyanide (in situ trichlorosilyl cyanide) was found to work efficiently for hydrocyanation of ketones to afford the corresponding cyanohydrins in high yield under mild conditions. Copyright Taylor & Francis Group, LLC.
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
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Paragraph 0460; 0461; 0462
(2016/09/26)
TYK2 INHIBITORS AND USES THEREOF
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
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Paragraph 00837; 00838
(2015/09/28)
ONE-POT SYNTHESIS OF α-CHLORONITRILES FROM ARYLCARBONYL COMPOUNDS
α-Chloronitriles are prepared by the reaction of arylcarbonyl compounds and trimethylsilyl cyanide with a stoichiometric amount of titanium tetrachloride in good yields.