138229-59-1Relevant articles and documents
Induction of apoptosis in MDA-MB-231 breast cancer cells by a PARP1-targeting PROTAC small molecule
Zhao, Qiuye,Lan, Tianlong,Su, Shang,Rao, Yu
, p. 369 - 372 (2019)
Poly (ADP-ribose) polymerase-1 (PARP1) is a major member of the PARP superfamily that is involved in DNA damage signalling and other important cellular processes. Here we report the development of a small molecule targeting PARP1 based on the PROTAC strategy. In the MDA-MB-231 cell line, the representative compound 3 can induce significant PARP1 cleavage and programmed cell death.
Synthesis method of methyl 3-formyl-2-nitrobenzoate
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Paragraph 0024; 0026; 0027; 0029, (2019/11/20)
The invention provides a synthesis method of methyl 3-formyl-2-nitrobenzoate. Firstly, methyl 3-methyl-2-nitrobenzoate is subjected to a substitution reaction with chlorine to obtain methyl 3-(dichloromethyl)-2-nitrobenzoate; the methyl 3-(dichloromethyl)
PROCESSES FOR THE PREPARATION OF NIRAPARIB AND INTERMEDIATES THEREOF
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Paragraph 00181; 00182, (2019/03/05)
The present invention relates to novel procedures and novel intermediates useful in the synthesis of Niraparib or any salt thereof.