63327-57-1Relevant articles and documents
A versatile and selective chemo-enzymatic synthesis of β-protected aspartic and γ-protected glutamic acid derivatives
Nuijens, Timo,Kruijtzer, John A.W.,Cusan, Claudia,Rijkers, Dirk T.S.,Liskamp, Rob M.J.,Quaedflieg, Peter J.L.M.
experimental part, p. 2719 - 2721 (2009/09/06)
Two versatile, high yielding, and efficient chemo-enzymatic methods for the synthesis of β-protected Asp and γ-protected Glu derivatives using Alcalase are described. The first method is based on the α-selective enzymatic hydrolysis of symmetrical aspartyl and glutamyl diesters. The second method involving mixed diesters comprises a three-step protocol using (i) α-selective enzymatic methyl-esterification, (ii) chemical β-esterification, and finally (iii) α-selective enzymatic methyl ester hydrolysis. The yields of the purified β- and γ-esters range from 77% to 91%.
Synthesis of β-(S-methyl)thioaspartic acid and derivatives
Heredia-Moya, Jorge,Kirk, Kenneth L.
, p. 5908 - 5913 (2008/12/21)
β-(S-Methyl)thioaspartic acid occurs as a posttranslational modification at position 88 in Escherichia coli ribosomal protein S12, a position that is a mutational hotspot resulting in both antibiotic-resistant and antibiotic-sensitive phenotypes. Critical
Straightforward and diastereoselective synthesis of tetrafunctionalized thiol synthons for the design of metallopeptidase inhibitors
David, Christelle,Bischoff, Laurent,Roques, Bernard P.,Fournié-Zaluski, Marie-Claude
, p. 209 - 215 (2007/10/03)
Tetrafunctionalized thiol-containing synthons with different side-chains have been prepared with good yields by a straightforward diastereoselective and general methodology. The key step of the synthesis consisted of a tandem reduction and Wittig-Horner r
