4-Bromo-1-chloro-2-(4-methoxy-benzyl)-benzene

Base Information Edit

Chemical Name:4-Bromo-1-chloro-2-(4-methoxy-benzyl)-benzene
CAS No.:333361-51-6
Molecular Formula:C14H12BrClO
Molecular Weight:0.00000
Hs Code.:
Mol file:333361-51-6.mol

Synonyms:

Suppliers and Price of 4-Bromo-1-chloro-2-(4-methoxy-benzyl)-benzene

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Bromo-1-chloro-2-[(4-methoxyphenyl)methyl]benzene
2.5g
$ 690.00

TRC
4-Bromo-1-chloro-2-[(4-methoxyphenyl)methyl]benzene
1g
$ 285.00

Total 14 raw suppliers

Chemical Property of 4-Bromo-1-chloro-2-(4-methoxy-benzyl)-benzene Edit

Chemical Property:

Boiling Point:379.8±32.0 °C(Predicted)
PSA：0.00000
Density:1.410±0.06 g/cm3(Predicted)
LogP:0.00000
Solubility.:Dichloromethane; Ethyl Acetate

Purity/Quality:

99%, ^*data from raw suppliers

4-Bromo-1-chloro-2-[(4-methoxyphenyl)methyl]benzene ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses 4-Bromo-1-chloro-2-[(4-methoxyphenyl)methyl]benzene is an intermediate in synthesizing Dapagliflozin-D5 (D185372), a labelled analogue of Dapagliflozin (D185370), which is a selective sodium-glucose cotransporter-2 inhibitor that reduces renal glucose reabsorption and is used to treat patients with type 2 diabetes.

Technology Process of 4-Bromo-1-chloro-2-(4-methoxy-benzyl)-benzene

There total 4 articles about 4-Bromo-1-chloro-2-(4-methoxy-benzyl)-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 333361-49-2
(5-bromo-2-chlorophenyl)(4-methoxyphenyl)methanone

: 333361-51-6
4-bromo-1-chloro-2-(4-methoxybenzyl)benzene

Guidance literature:: With triethylsilane; boron trifluoride diethyl etherate; In dichloromethane; acetonitrile; at 0 - 20 ℃; for 2.33333h; Inert atmosphere;

Reference yield:

: 21739-92-4
5-bromo-2-chlorobenzoic acid

: 333361-51-6
4-bromo-1-chloro-2-(4-methoxybenzyl)benzene

Guidance literature:: Multi-step reaction with 3 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 10 h / 20 °C

2.1: aluminum (III) chloride / dichloromethane / 1 h / -5 - 20 °C / Inert atmosphere

2.2: 2 h / -5 - 0 °C / Inert atmosphere

3.1: aluminum (III) chloride; sodium tetrahydroborate / tetrahydrofuran / 18 h / 5 - 20 °C / Inert atmosphere

With aluminum (III) chloride; sodium tetrahydroborate; oxalyl dichloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm401780b

Reference yield:

: 21900-52-7
5-bromo-2-chloro-benzoyl chloride

: 333361-51-6
4-bromo-1-chloro-2-(4-methoxybenzyl)benzene

Guidance literature:: Multi-step reaction with 2 steps

1.1: aluminum (III) chloride / dichloromethane / 1 h / -5 - 20 °C / Inert atmosphere

1.2: 2 h / -5 - 0 °C / Inert atmosphere

2.1: aluminum (III) chloride; sodium tetrahydroborate / tetrahydrofuran / 18 h / 5 - 20 °C / Inert atmosphere

With aluminum (III) chloride; sodium tetrahydroborate; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm401780b