N-(2-Chloroethyl)-4-MethylbenzenesulfonaMide

Base Information

• Chemical Name: N-(2-Chloroethyl)-4-MethylbenzenesulfonaMide
• CAS No.: 6331-00-6
• Molecular Formula: C9H12ClNO2S
• Molecular Weight: 233.719
• Mol file: 6331-00-6.mol

Synonyms:N-(2-chloroethyl)-4-methyl-benzenesulfonamide;(2-chloroethyl)[(4-methylphenyl)sulfonyl]amine;N-(2-Chlor-aethyl)-toluolsulfonamid-(4);benzenesulfonamide,n-(2-chloroethyl)-4-methyl;N-(2-Chlor-aethyl)-toluol-4-sulfonamid;N-(2-chloro-ethyl)-toluene-4-sulfonamide;

Chemical Property of N-(2-Chloroethyl)-4-MethylbenzenesulfonaMide

Chemical Property:

• Vapor Pressure: 3.06E-05mmHg at 25°C
• Boiling Point: 355.8°C at 760 mmHg
• Flash Point: 169°C
• PSA: 54.55000
• Density: 1.268g/cm³
• LogP: 2.98380

Purity/Quality:

98%min ^*data from raw suppliers

N-(2-Chloroethyl)-4-methylbenzenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-Chloroethyl)-4-MethylbenzenesulfonaMide

There total 10 articles about N-(2-Chloroethyl)-4-MethylbenzenesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

N-(p-toluenesulfonyl)aziridine (3634-89-7) → N-(2-chloroethyl)-4-methylbenzenesulfonamide (6331-00-6)

Guidance literature:

With chloro-trimethyl-silane; tetrabutyl ammonium fluoride; In tetrahydrofuran; at 40 ℃; for 12h;

DOI:10.1021/jo9913816

Reference yield: 98.0%

2-chloroethanamine hydrochloride (870-24-6) + p-toluenesulfonyl chloride (98-59-9) → N-(2-chloroethyl)-4-methylbenzenesulfonamide (6331-00-6)

Guidance literature:

2-chloroethanamine hydrochloride; With triethylamine; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

p-toluenesulfonyl chloride; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

DOI:10.1016/j.cclet.2021.11.082

Reference yield: 82.0%

quinoline (91-22-5) + N-(2-((1,3-diphenyl-1,3,2-diazaphospholidin-2-yl)oxy)ethyl)-4-methylbenzenesulfonamide + chloroformic acid ethyl ester (541-41-3) → N-(2-chloroethyl)-4-methylbenzenesulfonamide (6331-00-6) + ethyl 4-(2-oxido-1,3-diphenyl-1,3,2-diazaphospholidin-2-yl)quinoline-1(4H)-carboxylate + ethyl 2-(2-oxido-1,3-diphenyl-1,3,2-diazaphospholidin-2-yl)quinoline-1(2H)-carboxylate

Guidance literature:

quinoline; chloroformic acid ethyl ester; In dichloromethane; for 1h;

N-(2-((1,3-diphenyl-1,3,2-diazaphospholidin-2-yl)oxy)ethyl)-4-methylbenzenesulfonamide; In dichloromethane; at 40 ℃; for 12h;

DOI:10.1021/acs.orglett.7b03829

upstream raw materials:

ethanolamine

p-toluenesulfonyl chloride

N-(2-hydroxy-ethyl)-4-methyl-benzenesulfonamide

2-chloroethanamine hydrochloride

Downstream raw materials:

N-(2-tosylaminoethyl)-1,3-propanediamine

N-(2-azidoethyl)-4-methylbenzenesulfonamide

N-Nitroso-N-<2-isopropyloxy-ethyl>-p-toluolsulfonamid

N¹,N⁵-ditosyl-3-azapentane-1,5-diamine

Refernces

• 1、 Liu, Chuanhao,Man, Huizi,Xiao, Yi,Xie, Lijuan,Zheng, Ying,Zhou, Lin. "Forthrightly monitoring ferroptosis induced by endoplasmic reticulum stresses through fluorescence lifetime imaging of microviscosity increases with a specific rotor". supporting information. . Retrieved 2022/01/08.
• 2、 Hwang, Joon Young,Shin, Jung Ha,Seong, Eun Young,Kang, Eun Joo. "FeCl2-mediated Nucleophilic Chlorination of Iodoalkanes Accelerated by Phenanthroline Ligand". . p. 695 - 698. Retrieved 2018/04/17.