98-59-9Relevant articles and documents
Facile synthesis of sulfonyl chlorides
Huang, Jianxing,Widlanski, Theodore S.
, p. 2657 - 2660 (1992)
A method for the synthesis of sulfonyl chlorides and bromides from the corresponding sulfonate salts is described. The method gives good yields of the acid halides under very mild conditions, and is compatible with both acid and base sensitive functionalities.
Investigation on recovery of p-mephso3k based on solid-liquid equilibrium of the p-mephso3k-k2co3-h2o system
Shuanghong, Hao,Jie, Xu,Mengqi, Chen,Yan, Wei
, p. 1249 - 1254 (2021/03/01)
In this article, we propose a method of recovering p-MePhSO3K from the industrial by-product of quizalofop-p-ethyl. The phase diagram of the solid-liquid equilibrium system of p-MePhSO3K2CO3-H2O at the temperatures of 15, 25, 35, 45, and 55°C was determined and plotted. Based on the phase diagram of 25°C, the separation and recovery process of p-MePhSO3K from the p-MePhSO3K2CO3-H2O system was designed by analyzing the crystallization fields. First, p-MePhSO3K and K2CO3 were crystallized from wastewater in turn through evaporation separation. Then, the crystallized p-MePhSO3K was purified further by washing with ethanol. Finally, the pure p-MePhSO3K was transformed into the intermediate p-toluenesulfonyl chloride and then the intermediate L-p-toluenesulfonate ethyl lactate for quizalofop-p-ethyl production.
Method for continuously synthesizing P-toluenesulfonyl chloride
-
Paragraph 0089-0150, (2021/11/03)
The method comprises the following steps: toluene, sulfur trioxide, chlorosulfonic acid, an organic base and a solvent are mixed in first static mixers, and then pumped into first microreactors to react. The first Micro-reactor outlet discharged first reaction mixture flows into second static mixer and mixed with sulfur trioxide, chlorosulfonic acid, low carbon chain fatty acid and solvent pumped into second static mixers respectively, and the resulting mixed materials are pumped into second microreactors to react. The second The secondary reaction mixture discharged from the microreactor was cooled, crystallized and isolated to yield p-toluenesulfonyl chloride as a product. To the method, the production efficiency is greatly improved; due to the addition of the sulfone inhibitor, the problems that a large amount of sulfone substances and polysulfonate are easily generated by sulfonation of sulfur trioxide are effectively solved, and hydrogen chloride gas is prevented from being generated.
Facile synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazides
Chen, Rongxiang,Xu, Shaohong,Shen, Fumin,Xu, Canran,Wang, Kaikai,Wang, Zhanyong,Liu, Lantao
, (2021/09/20)
A simple and rapid method for efficient synthesis of sulfonyl chlorides/bromides from sulfonyl hydrazide with NXS (X = Cl or Br) and late-stage conversion to several other functional groups was described. A variety of nucleophiles could be engaged in this transformation, thus permitting the synthesis of complex sulfonamides and sulfonates. In most cases, these reactions are highly selective, simple, and clean, affording products at excellent yields.