4'-FLUORO-2-PHENYLACETOPHENONE

Base Information

• Chemical Name: 4'-FLUORO-2-PHENYLACETOPHENONE
• CAS No.: 347-84-2
• Molecular Formula: C14H11FO
• Molecular Weight: 214.239
• Hs Code.: 2914700090
• Mol file: 347-84-2.mol

Synonyms:Acetophenone,4'-fluoro-2-phenyl- (6CI,8CI);1-(4-Fluorophenyl)-2-phenylethan-1-one;1-(4-Fluorophenyl)-2-phenylethanone;1-(p-Fluorophenyl)-2-phenylethanone;NSC254073;

Chemical Property of 4'-FLUORO-2-PHENYLACETOPHENONE

Chemical Property:

• Melting Point: 83-84 °C
• Boiling Point: 332.9 °C at 760 mmHg
• Flash Point: 137.9 °C
• PSA: 17.07000
• Density: 1.152 g/cm³
• LogP: 3.25110
• Storage Temp.: 2-8°C
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%,99%, ^*data from raw suppliers

Benzyl 4-Fluorophenyl Ketone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 1-(4-Fluorophenyl)-2-phenyl-ethanone is used in the preparation and evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors.

Technology Process of 4'-FLUORO-2-PHENYLACETOPHENONE

There total 53 articles about 4'-FLUORO-2-PHENYLACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

fluorobenzene (462-06-6) + phenylacetyl chloride (103-80-0) → 1-(4-fluorophenyl)-2-phenylethanone (347-84-2)

Guidance literature:

With ammonium chloride; at -10 - 0 ℃; for 2h; Inert atmosphere;

Reference yield: 90.0%

bromobenzene (108-86-1,52753-63-6) + 1-(4-fluorophenyl)ethanone (403-42-9) → 1-(4-fluorophenyl)-2-phenylethanone (347-84-2)

Guidance literature:

With C₁₆H₁₄N₆O₄Pd; potassium tert-butylate; In acetonitrile; at 82 ℃; for 2h; Schlenk technique; Reflux;

DOI:10.1007/s11243-017-0148-6

Reference yield: 90.0%

fluorobenzene + phenylacetyl chloride (103-80-0) → 1-(4-fluorophenyl)-2-phenylethanone (347-84-2)

Guidance literature:

With aluminum (III) chloride; at 10 ℃; for 1h;

DOI:10.1080/00397911.2015.1111382

upstream raw materials:

fluorobenzene

phenylacetyl chloride

1-(4-fluorophenyl)-1-phenylethylene

(4-fluorophenyl)phenylacetylene

Downstream raw materials:

4-fluoro-deoxybenzoin semicarbazone

2-(4-fluoro-phenyl)-3-phenyl-quinoline-4-carboxylic acid

6-bromo-2-(4-fluoro-phenyl)-3-phenyl-quinoline-4-carboxylic acid

2-(4-fluorophenyl)-3-phenyl-1H-indole

Refernces

• 1、 Luo, Mengqiang,Zhang, Yaohong,Fang, Ping,Li, Yan,Qi, Chenze,Li, Yong,Shen, Runpu,Cheng, Kai,Wang, Hai. "H2O2-mediated room temperature synthesis of 2-arylacetophenones from arylhydrazines and vinyl azides in water". supporting information. p. 630 - 635. Retrieved 2022/02/01.
• 2、 Dong, Shunxi,Feng, Xiaoming,He, Jun,Liu, Wen,Liu, Xiaohua,Pu, Maoping,Wu, Yun-Dong,Zhang, Tinghui. "Iron-Catalyzed Enantioselective Radical Carboazidation and Diazidation of α,β-Unsaturated Carbonyl Compounds". . p. 11856 - 11863. Retrieved 2021/08/16.