1-fluoro-4-(1-phenylethenyl)benzene

Base Information

• Chemical Name: 1-fluoro-4-(1-phenylethenyl)benzene
• CAS No.: 395-21-1
• Molecular Formula: C14H11 F
• Molecular Weight: 198.24
• Mol file: 395-21-1.mol

Synonyms:

Chemical Property of 1-fluoro-4-(1-phenylethenyl)benzene

Chemical Property:

• Vapor Pressure: 0.00783mmHg at 25°C
• Boiling Point: 277°Cat760mmHg
• Flash Point: 121.4°C
• Density: 1.065g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-fluoro-4-(1-phenylethenyl)benzene

There total 32 articles about 1-fluoro-4-(1-phenylethenyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-fluorobenzophenone (345-83-5) + Methyltriphenylphosphonium bromide (1779-49-3) → 1-(4-fluorophenyl)-1-phenylethylene (395-21-1)

Guidance literature:

Methyltriphenylphosphonium bromide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

4-fluorobenzophenone; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1002/anie.201504109

Reference yield: 92.0%

Cinnamic acid (621-82-9) + 1-Bromo-4-fluorobenzene (460-00-4) → 1-(4-fluorophenyl)-1-phenylethylene (395-21-1)

Guidance literature:

Cinnamic acid; With potassium tert-butylate; In ethanol; at 20 ℃; for 1h; Inert atmosphere; Sealed tube;

1-Bromo-4-fluorobenzene; With palladium(II) acetylacetonate; 1,10-Phenanthroline; tris-(o-tolyl)phosphine; copper(I) bromide; In 1-methyl-pyrrolidin-2-one; quinoline; ethanol; at 170 ℃; for 16h; Inert atmosphere; Sealed tube;

DOI:10.1002/anie.201605744

Reference yield: 92.0%

triphenylboroxine (3262-89-3) + 1-(4-fluorophenyl)ethanone (403-42-9) → 1-(4-fluorophenyl)-1-phenylethylene (395-21-1)

Guidance literature:

With tetrakis(triphenylphosphine)nickel⁽⁰⁾; water; 1,2-bis-(dicyclohexylphosphino)ethane; In diethylene glycol dimethyl ether; at 110 ℃; for 24h; Glovebox; Schlenk technique; Inert atmosphere;

DOI:10.1021/jacs.7b02742

upstream raw materials:

methyl magnesium iodide

4-fluorobenzophenone

4-fluoro-1-iodobenzene

1--1-phenylethene

Downstream raw materials:

C₂₄H₂₅FO₅

1-fluoro-4-(1-phenylethyl)-benzene

1-(4-fluorophenyl)-2-phenylethanone

2-(4-fluorophenyl)-1-phenylethanone

Refernces

• 1、 Cheng, Hanchao,Lam, Tsz-Lung,Liu, Yungen,Tang, Zhou,Che, Chi-Ming. "Photoinduced Hydroarylation and Cyclization of Alkenes with Luminescent Platinum(II) Complexes". supporting information. p. 1383 - 1389. Retrieved 2020/11/30.
• 2、 Jiang, Yimin,Shi, Zhaojiang,Wu, Jinnan,Wu, Shaofen,Ye, Keyin,Yu, Yi,Yuan, Yaofeng. "Electrochemistry enabled selective vicinal fluorosulfenylation and fluorosulfoxidation of alkenes". supporting information. . Retrieved 2021/11/17.