Ethyl 1-piperidineacetate

Base Information

• Chemical Name: Ethyl 1-piperidineacetate
• CAS No.: 23853-10-3
• Molecular Formula: C9H17 N O2
• Molecular Weight: 171.239
• Hs Code.: 2933399090
• European Community (EC) Number: 607-278-8
• DSSTox Substance ID: DTXSID00349188
• Nikkaji Number: J1.553.348J
• Wikidata: Q82124268
• Mol file: 23853-10-3.mol

Synonyms:Ethyl 1-piperidineacetate;23853-10-3;ethyl piperidin-1-ylacetate;ethyl 2-(piperidin-1-yl)acetate;ethyl 2-piperidin-1-ylacetate;1-piperidineacetic acid, ethyl ester;MFCD00134496;Ethyl Piperidine-1-Acetate;ethyl 1-piperidine acetate;Ethyl 2-Piperidinylacetate;SCHEMBL865518;Ethyl 1-piperidineacetate, 98%;Piperidinoacetic acid ethyl ester;DTXSID00349188;Ethyl 2-(piperidin-1-yl)-acetate;piperidinyl acetic acid ethyl ester;AC2282;AKOS000121033;Piperadin-1-yl-acetic acid ethyl ester;Piperidin-1-yl-acetic acid ethyl ester;SB41224;CS-10023;SY005321;BB 0262986;FT-0625842;EN300-18265;A878121;J-015238;Z57725240

Chemical Property of Ethyl 1-piperidineacetate

Chemical Property:

• Appearance/Colour: clear light yellow liquid
• Vapor Pressure: 0.0836mmHg at 25°C
• Refractive Index: n20/D 1.453(lit.)
• Boiling Point: 226°Cat760mmHg
• PKA: 7.44±0.10(Predicted)
• Flash Point: 91.1°C
• PSA: 29.54000
• Density: 0.997g/cm³
• LogP: 0.97330
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 171.125928785
• Heavy Atom Count: 12
• Complexity: 142

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethyl 1-piperidineacetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCOC(=O)CN1CCCCC1
• Uses: Reactant for synthesis of: Nicotinic acid receptor agonists for treatment of dyslipidemia 1-Alkylcyclanols with side chain functions Benzhydrylamides for pharmacochemical studiesReactant for: Elimination reactions Hydrogenation of esters to alcohols

Technology Process of Ethyl 1-piperidineacetate

There total 14 articles about Ethyl 1-piperidineacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

piperidine (110-89-4) + diazoacetic acid ethyl ester (623-73-4) → piperidin-1-yl-acetic acid ethyl ester (23853-10-3)

Guidance literature:

With acetone; In toluene; at 20 ℃; for 0.05h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c6cc10005h

Reference yield: 81.8%

piperidine (110-89-4) + ethyl bromoacetate (105-36-2) → piperidin-1-yl-acetic acid ethyl ester (23853-10-3)

Guidance literature:

In benzene; at 20 ℃; for 2h;

Reference yield: 80.0%

piperidine (110-89-4) + chloroacetic acid ethyl ester (105-39-5) → piperidin-1-yl-acetic acid ethyl ester (23853-10-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 12h; Time;

upstream raw materials:

piperidine

chloroacetic acid ethyl ester

ethyl bromoacetate

Trifluoro-methanesulfonate1-(tert-butyl-dimethyl-silanyloxy)-1-methyl-piperidinium;

Downstream raw materials:

1-ethoxycarbonylmethyl-1-methyl-piperidinium; iodide

1-piperidinoethanol

piperidinoacetic acid

ethyl trans-3-(3-nitrophenyl)oxirane-2-carboxylate

Refernces

• 1、 Chen, Zimin,Hu, Yuanyuan,Li, Weirong,Liao, Zixuan,Xi, Xiaoxiang,Yuan, Weiming,Zheng, Songlin. "Selective 1,2-Aryl-Aminoalkylation of Alkenes Enabled by Metallaphotoredox Catalysis". supporting information. p. 17910 - 17916. Retrieved 2020/08/21.
• 2、 Chen, Lianfen,Cui, Hao,Wang, Yanhu,Liang, Xiang,Zhang, Li,Su, Cheng-Yong. "Carbene insertion into N-H bonds with size-selectivity induced by a microporous ruthenium-porphyrin metal-organic framework". supporting information. p. 3940 - 3946. Retrieved 2018/03/21.