4-(5-broMo-2-chlorobenzyl)phenol

Base Information

• Chemical Name: 4-(5-broMo-2-chlorobenzyl)phenol
• CAS No.: 864070-18-8
• Molecular Formula: C13H10BrClO
• Molecular Weight: 297.579
• Hs Code.: 2908199090
• Mol file: 864070-18-8.mol

Synonyms:

Chemical Property of 4-(5-broMo-2-chlorobenzyl)phenol

Chemical Property:

• Boiling Point: 401.3±35.0 °C(Predicted)
• PKA: 10.14±0.15(Predicted)
• PSA: 20.23000
• Density: 1.522±0.06 g/cm3(Predicted)
• LogP: 4.39890
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99.0%, High purity. ^*data from raw suppliers

4-(5-Bromo-2-chlorobenzyl)phenol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-(5-Bromo-2-chlorobenzyl)phenol can be used to treat diabetes or any related diseases.

Technology Process of 4-(5-broMo-2-chlorobenzyl)phenol

There total 13 articles about 4-(5-broMo-2-chlorobenzyl)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene (461432-23-5) → 4-(5-bromo-2-chlorobenzyl)phenol (864070-18-8)

Guidance literature:

With boron tribromide; sodium hydrogencarbonate; In dichloromethane; at 20 - 30 ℃; for 0.5h; Inert atmosphere;

Reference yield: 98.0%

4-bromo-1-chloro-2-(4-methoxybenzyl)benzene (333361-51-6) → 4-(5-bromo-2-chlorobenzyl)phenol (864070-18-8)

Guidance literature:

4-bromo-1-chloro-2-(4-methoxybenzyl)benzene; With boron tribromide; In dichloromethane; at 20 ℃; for 2h;

With potassium carbonate; In dichloromethane; water; at 20 ℃;

With hydrogenchloride; In dichloromethane; water; pH=1;

Reference yield: 94.8%

(5-bromo-2-chlorophenyl)(4-hydroxyphenyl)methanone (1360568-68-8) → 4-(5-bromo-2-chlorobenzyl)phenol (864070-18-8)

Guidance literature:

With triethylsilane; boron trifluoride diethyl etherate; In diethyl ether; dichloromethane; acetonitrile; at 20 ℃; for 16h; Inert atmosphere;

upstream raw materials:

4-bromo-1-chloro-2-(4-methoxybenzyl)benzene

4-bromo-1-chloro-2-[(4-ethoxyphenyl)methyl]benzene

5-bromo-2-chlorobenzoic acid

phenol

Downstream raw materials:

2-(4-(5-bromo-2-chlorobenzyl)phenoxy)ethanol

1-(4-(5-bromo-2-chlorobenzyl)phenoxy)propan-2-ol

4-bromo-1-chloro-2-[[4-[2-(cyclopropyloxy)ethoxy]phenyl]methyl]benzene

O-4-(5-bromo-2-chlorobenzyl)phenyl dimethylcarbamothioate

Refernces

• 1、 -. "Synthetic method for empagliflozin related substance IMPD". Paragraph 0079; 0083. . Retrieved 2019/07/10.
• 2、 -. "Dicyclic derivative of glucoside as well as preparation method and application of dicyclic derivative". Paragraph 0217; 0218; 0219. . Retrieved 2018/07/30.