2',4'-DIHYDROXY-3'-METHYLACETOPHENONE

Base Information

• Chemical Name: 2',4'-DIHYDROXY-3'-METHYLACETOPHENONE
• CAS No.: 10139-84-1
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Mol file: 10139-84-1.mol

Synonyms:Acetophenone, 2',4'-dihydroxy-3'-methyl- (6CI);1-(2,4-Dihydroxy-3-methylphenyl)ethanone;3-Methylresacetophenone;4-Acetyl-2-methylresorcinol;

Chemical Property of 2',4'-DIHYDROXY-3'-METHYLACETOPHENONE

Chemical Property:

• Appearance/Colour: orange-brown powder
• Vapor Pressure: 4.29E-05mmHg at 25°C
• Melting Point: 150-154 °C
• Refractive Index: 1.583
• Boiling Point: 340.7 °C at 760 mmHg
• PKA: 8.32±0.23(Predicted)
• Flash Point: 174 °C
• PSA: 57.53000
• Density: 1.239 g/cm³
• LogP: 1.60880

Purity/Quality:

98%,99%, ^*data from raw suppliers

2'',4''-Dihydroxy-3''-methylacetophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: chemo selective benzylation of 2,4-dihydroxy-3-methylacetophenone gave the 4-benzyloxy derivative. 4- Ethyl-6 methyl resorcinol was prepared by Clemmensen reduction of 4-dihydroxy-3- methylacetophenone.

Technology Process of 2',4'-DIHYDROXY-3'-METHYLACETOPHENONE

There total 10 articles about 2',4'-DIHYDROXY-3'-METHYLACETOPHENONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methylbenzene-1,3-diol (608-25-3) + acetic anhydride (108-24-7) → 1-(2,4-dihydroxy-3-methylphenyl)ethanone (10139-84-1)

Guidance literature:

With boron trifluoride diethyl etherate; at 80 ℃; for 6h;

DOI:10.1055/s-2002-33919

Reference yield: 88.4%

2-methylbenzene-1,3-diol (608-25-3) → 1-(2,4-dihydroxy-3-methylphenyl)ethanone (10139-84-1)

Guidance literature:

In (2S)-N-methyl-1-phenylpropan-2-amine hydrate;

Reference yield: 60.0%

2-methylbenzene-1,3-diol (608-25-3) + acetic anhydride (108-24-7) → 1-(2,4-dihydroxy-3-methylphenyl)ethanone (10139-84-1) + 1,5-diacetyl-2,5-dihydroxy-3-methylbenzene (22304-66-1)

Guidance literature:

With zinc(II) chloride; at 142 ℃; for 0.25h;

upstream raw materials:

2-methylbenzene-1,3-diol

acetonitrile

2',4'-dihydroxy-4-acetophenone

methyl iodide

Downstream raw materials:

2-hydroxy-4-(2'-oxo-cyclohexyloxy)-3-methylacetophenone

7-ethoxy-2-ethyl-8-((4-(2-oxo-2-phenylacetyl)piperazin-1-yl)methyl)-4H-chromen-4-one

7-ethoxy-2-ethyl-8-((4-(2-oxo-3-phenylpropanoyl)piperazin-1-yl)methyl)-4H-chromen-4-one

C₁₄H₁₈O₅

Refernces

• 1、 Dhanya, Raveendra-Panickar,Sheffler, Douglas J.,Dahl, Russell,Davis, Melinda,Lee, Pooi San,Yang, Li,Nickols, Hilary Highfield,Cho, Hyekyung P.,Smith, Layton H.,D'Souza, Manoranjan S.,Conn, P. Jeffrey,Der-Avakian, Andre,Markou, Athina,Cosford, Nicholas D.P.. "Design and synthesis of systemically active metabotropic glutamate subtype-2 and -3 (mGlu2/3) receptor positive allosteric modulators (PAMs): Pharmacological characterization and assessment in a rat model of cocaine dependence". . p. 4154 - 4172. Retrieved 2014/06/09.
• 2、 -. "Fibrinogen receptor antagonists and their use". Page/Page column 97. . Retrieved 2010/08/04.