4H-1-Benzopyran-4-one, 7-hydroxy-5,8-dimethoxy-2-(2-methoxyphenyl)-

Base Information

• Chemical Name: 4H-1-Benzopyran-4-one, 7-hydroxy-5,8-dimethoxy-2-(2-methoxyphenyl)-
• CAS No.: 102273-92-7
• Molecular Formula: C18H16O6
• Molecular Weight: 328.321
• Mol file: 102273-92-7.mol

Synonyms:

Chemical Property of 4H-1-Benzopyran-4-one, 7-hydroxy-5,8-dimethoxy-2-(2-methoxyphenyl)-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4H-1-Benzopyran-4-one, 7-hydroxy-5,8-dimethoxy-2-(2-methoxyphenyl)-

There total 8 articles about 4H-1-Benzopyran-4-one, 7-hydroxy-5,8-dimethoxy-2-(2-methoxyphenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2',4'-dihydroxy-2,3',6'-trimethoxychalcone (100079-39-8) → 7-hydroxy-5,8,2'-trimethoxyflavone (102273-92-7)

Guidance literature:

With iodine; In dimethyl sulfoxide;

DOI:10.1016/j.ejmech.2017.09.046

Reference yield:

2,5-dimethoxyresorcinol (20032-42-2) → 7-hydroxy-5,8,2'-trimethoxyflavone (102273-92-7)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / 40 °C

2: iodine / dimethyl sulfoxide

With boron trifluoride diethyl etherate; iodine; In dimethyl sulfoxide; 1: |Friedel-Crafts Acylation;

DOI:10.1016/j.ejmech.2017.09.046

Reference yield:

2-hydroxyresorcinol (87-66-1) → 7-hydroxy-5,8,2'-trimethoxyflavone (102273-92-7)

Guidance literature:

Multi-step reaction with 7 steps

1: potassium iodide; potassium carbonate / acetone / 48 h / Reflux

2: acetic acid; nitric acid / 4 h / 40 °C

3: sodium dithionite / ethyl acetate; water / 20 °C

4: sodium hydroxide / ethanol / 20 °C / pH 8 - 9

5: hydrogen; palladium 10% on activated carbon / methanol / 8 h / 20 °C

6: boron trifluoride diethyl etherate / 40 °C

7: iodine / dimethyl sulfoxide

With sodium dithionite; palladium 10% on activated carbon; boron trifluoride diethyl etherate; hydrogen; iodine; nitric acid; potassium carbonate; acetic acid; potassium iodide; sodium hydroxide; In methanol; ethanol; water; dimethyl sulfoxide; ethyl acetate; acetone; 6: |Friedel-Crafts Acylation;

DOI:10.1016/j.ejmech.2017.09.046

upstream raw materials:

2,5-dimethoxyresorcinol

2-hydroxyresorcinol

1,2,3-tris-benzyloxybenzene

2,6-bis-benzyloxy-[1,4]benzoquinone

Downstream raw materials:

5,7,8,2'-tetramethoxyflavone

Refernces