H-Glu(OMe)-OtBu

Base Information

• Chemical Name: H-Glu(OMe)-OtBu
• CAS No.: 34582-33-7
• Molecular Formula: C10H19NO4.ClH
• Molecular Weight: 253.726
• Hs Code.: 2922499990
• Mol file: 34582-33-7.mol

Synonyms:L-Glutaminsaeure-1-tert-butyl-5-methylester-hydrochlorid;(S)-1-tert-butyl 5-methyl 2-aminopentanedioate hydrochloride;L-Glutamic acid,1-(1,1-dimethylethyl) 5-methyl ester,hydrochloride;1-(1,1-dimethylethyl) 5-methyl-L-glutamate hydrochloride;HCl*Glu(OMe)-OBut;

Chemical Property of H-Glu(OMe)-OtBu

Chemical Property:

• PSA: 78.62000
• LogP: 2.11090
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

H-Glu(ome)-otbuhydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: H-Glu(ome)-otbu hcl

Technology Process of H-Glu(OMe)-OtBu

There total 5 articles about H-Glu(OMe)-OtBu which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

γ-methyl L-glutamate hydrochloride (3077-51-8) + isobutene (115-11-7,15220-85-6) → α-tert-butyl-γ-methyl L-Glu diester hydrochloride (34582-33-7)

Guidance literature:

With sulfuric acid; In tetrahydrofuran; for 18h; Ambient temperature;

DOI:10.1016/0040-4020(89)80144-9

Reference yield:

Glutamic acid (617-65-2,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → 2-Amino-pentanedioic acid 1-tert-butyl ester 5-methyl ester; hydrochloride (23736-76-7,34582-33-7,36134-51-7)

Guidance literature:

Multi-step reaction with 2 steps

1: HCl

2: cc. H₂SO₄ / tetrahydrofuran / Ambient temperature

With hydrogenchloride; sulfuric acid; In tetrahydrofuran;

DOI:10.1016/0040-4020(89)80144-9

Reference yield:

L-glutamic acid (56-86-0,21675-62-7,23009-64-5,25104-13-6,84960-48-5,25513-46-6) → α-tert-butyl-γ-methyl L-Glu diester hydrochloride (34582-33-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / HCl / 0.01 h

2: 60 percent / cc. H₂SO₄ / tetrahydrofuran / 18 h / Ambient temperature

With hydrogenchloride; sulfuric acid; In tetrahydrofuran;

DOI:10.1016/0040-4020(89)80144-9

upstream raw materials:

DL-glutamic acid-γ-methyl ester hydrochloride

isobutene

Glutamic acid

diazomethane

Downstream raw materials:

N-(benzyloxycarbonyl)-γ-L-glutamyl-L-glutamic acid, α,α'-di-tert-butyl γ-methyl triester

(S)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-formyl-amino]-benzoylamino}-pentanedioic acid 1-tert-butyl ester

α-tert-butyl γ-methyl N'-<4--N-methylamino>benzoyl>-L-glutamate

t-butyl 2-tritylamino-4-carbomethoxy-5-hydroxy-5-(4-nitrophenyl)-(2S)-pentanoate

Refernces

• 1、 Losse,Raddatz,Naumann,Kossowicz. "Insulin polyamino acid complexes, a variable principle to get retard forms". . p. 105 - 109. Retrieved 2007/10/02.